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  • 1
    ISSN: 1432-1106
    Keywords: Septum ; Supraoptic nucleus ; Vasopressin ; Oxytocin ; Electrophysiology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In order to see whether septal neurones are connected to the hypothalamic neurones secreting vasopressin or oxytocin, neurones in different regions of the septum were recorded during electrical stimulation of the supraoptic nucleus. The position of the stimulating electrode within the latter was verified using lactating rats in which milk ejections could be induced by a train of electrical pulses applied to the nucleus. The responses of septal neurones to single pulse stimulation were then analysed by post-stimulus time histograms. In the septum ipsilateral to the site of stimulation, 42% of the neurones were antidromically invaded, 20% were orthodromically excited and 21% were inhibited following supraoptic stimulation. In the contralateral septum, 2% of the cells tested were antidromically invaded, 3% were excited and 16% inhibited. In the medial septum, 14% of the neurones were orthodromically excited, and 48% were inhibited. These results provide electrophysiological evidence for direct connections between septal neurones and the ipsilateral supraoptic nucleus of the hypothalamus, and give further support to the hypothesis of a septal influence on the activity of vasopressin- or oxytocin-releasing cells in the magnocellular system.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 47 (1982), S. 203-208 
    ISSN: 1432-1106
    Keywords: Septum ; Supraoptic nucleus ; Oxytocin ; Milk ejection ; Electrophysiology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Extracellular recordings from neurones in the lateral septum were performed in urethane anaesthetised lactating rats to study the eventual role of the septum in the control of suckling-induced oxytocin release. The connections of these neurones with the supraoptic nucleus, which contains cells secreting oxytocin, were assessed electrophysiologically by single pulse stimulation of the ipsilateral supraoptic nucleus. The neurones were thus classified into four categories: antidromically activated, orthodromically activated or inhibited, and unresponsive neurones. One hundred septal neurones were recorded in animals not exposed to suckling. A second group of 40 cells were analysed during suckling and one or more reflex milk ejections. The mean firing rates of each category of septal neurone did not differ significantly during suckling from the values observed in the absence of suckling. During suckling, almost all the recorded septal cells showed no significant alteration in their level of firing in relation to milk ejections. Two neurones presented an activation in the period between two milk ejections that seemed related to arousal. One neurone was clearly inhibited at the time of milk ejection. Our observations suggest that the septum does not represent an essential component of the pathways necessary for the milk ejection reflex induced by suckling, although it could exert an inhibitory action modulating either the intervals between two successive milk ejections, or the amount of oxytocin released.
    Type of Medium: Electronic Resource
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