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Somatostatin and Alzheimer's disease: a hypothesis (1986)

Reubi, J. C. ; Palacios, J.

Springer

Journal of neurology 233 (1986), S. 370-372

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ISSN: 1432-1459

Keywords: Alzheimer's disease ; Somatostatin ; Endocrine system ; Amyloid

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Recent data suggest a disturbance of some brain somatostatin neurons in Alzheimer's disease. Moreover, some endocrine activities known to be regulated by somatostatin, such as growth hormone, thyroid-stimulating-hormone, somatomedins, as well as insulin and glucose metabolism, also seem to be affected in some patients. It is speculated that these changes are due to a global CNS and endocrine somatostatin defect in Alzheimer's disease and that the described endocrine imbalance may indirectly be responsible for at least part of the CNS pathology.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00313925

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