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  • 1995-1999  (2)
  • Cochlear reperfusion injury  (1)
  • Endolymph  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Appearance of free radicals in the guinea pig inner ear after noise-induced acoustic trauma (1995)
    Springer
    European archives of oto-rhino-laryngology and head & neck 252 (1995), S. 504-508 
    Details
    ISSN: 1434-4726
    Keywords: Noise trauma ; Superoxide anion radicals ; Strial blood flow ; Cochlear reperfusion injury
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The emergence of superoxide anion radicals (O2-) in the guinea pig inner ear following acoustic trauma was investigated by histochemical methods. Five minutes after exposure to sound at 120–125 dB SPL for 3 h, an O2- reaction product was detected in the cochlea along the luminal membrane of the marginal cells of the stria vascularis. This reaction product could not be found at 30 min, but reappeared at 2 h. The first appearance of O2- is not explainable by our studies, but the second appearance may be related to recirculation of strial blood flow after blood flow stasis. The present observations raise the possibility that free radicals are produced in the inner ear after acoustic trauma and lead to inner ear damage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02114761
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Regulation of inner ear fluid in the guinea pig cochlea after the application of saturated NaCl solution to the round window membrane (1999)
    Springer
    European archives of oto-rhino-laryngology and head & neck 256 (1999), S. S2 
    Details
    ISSN: 1434-4726
    Keywords: Key words Clochlear physiology ; Potassium ion and ; sodium ion transport ; Endolymph ; Perilymph
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The regulation of K+ and Na+ in the inner ear fluid of the guinea pig was studied after the application of saturated NaCl solution to the round window membrane. K+ and Na+ activities in the scala tympani increased rapidly and then decreased. K+ activity in the scala media increased immediately, but Na+ activity continued to increase during the period of observation. K+ activity in the scala vestibuli continued to increase in the observation period. Na+ activity in the scala vestibuli increased and then decreased. The endocochlear potential decreased immediately to approximately 20% of its initial level. Total activities of K+ and Na+ increased immediately and then decreased in both the scala tympani and scala media. The total activity of K+ and Na+ increased slowly and showed no regulatory decrease in the scala vestibuli. Thus, changing patterns in the total activity of K+ and Na+ were similar for the scala tympani and scala media, but not for the scala media and the scala vestibuli. Different patterns of K+ and Na+ activities among the three scalae indicate that their mechanisms for regulating inner ear fluid differ.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00014147
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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