Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Electronic Resource  (2)
  • Adrenergic mechanisms  (1)
  • Endopeptidase inhibition  (1)
Source
Material
  • Electronic Resource  (2)
Years
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Beta-adrenergic mechanisms in the nasal mucosa vascular bed (1995)
    Springer
    European archives of oto-rhino-laryngology and head & neck 252 (1995), S. 298-303 
    Details
    ISSN: 1434-4726
    Keywords: Nasal mucosa ; Adrenergic mechanisms ; β2-agonist ; β3agonist ; Propranolol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In thiopentone-anesthetized mature pigs (n = 7), local intra-arterial infusion of the β2-adrenoceptor agonists terbutaline and salbutamol and the β3-agonist BRL 37344 induced dose-dependent increases in nasal arterial blood flow (BF) and volume of the nasal mucosa (reflecting capacitance vessel function). Increases were also found in the laser Doppler flowmeter signal, reflecting superficial mucosal BE. In contrast to terbutaline and salbutamol, BRL 37344 showed marked effects on volume. Pretreatment with the β-adrenoceptor blocker propranolol significantly reduced the vasodilatory effects of terbutaline and salbutamol, whereas the BF increase evoked by BRL 37344 was not affected. Exogenous noradrenaline (NA) induced in vitro dose-dependent contractions of human nasal mucosa biopsies obtained from patients with non-allergic chronic rhinitis (n = 21) or non-allergic nasal polyposis (NANP, n = 16). On a molar basis, the contractile effect of NA was significantly greater in nasal mucosa samples without histological abnormalities when compared to biopsies with abundant inflammatory cells and edema within the submucosa. In the presence of propranolol, the vasoconstrictor effect of NA was significantly enhanced in biopsies with abundant inflammatory cells obtained from patients with NANP (P〈0.01). This observation suggests the possible occurrence of a β2 hyper-reactivity in the nasal mucosa of patients with NANP. After precontraction in a Krebs-Ringer solution with 50 nM K+, all nasal biopsies studied showed dose-dependent relaxation to terbutaline, salbutamol and BRL 37344. This relaxant effect was markedly reduced after pretreatment with propranolol. These observations suggest that β2- and β3-adrenergic vasodilatatory mechanisms may be similar in the nasal mucosa of the pig and man.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00185393
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Functional effects of phosphoramidon and captopril on exogenous neuropeptides in human nasal mucosa (1995)
    Springer
    European archives of oto-rhino-laryngology and head & neck 252 (1995), S. 83-85 
    Details
    ISSN: 1434-4726
    Keywords: Human nasal mucosa ; Sensory neuropeptides ; Endopeptidase inhibition ; Phosphoramidon ; Captopril
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The functional effects of the intranasal application of exogenous vasoactive intestinal polypeptide (VIP), substance P (SP) and calcitonin gene-related peptide (CGRP) were evaluated in 12 healthy volunteers before and after neutral endopeptidase (NEP) inhibition with phosphoramidon (PA) and angiotensin-converting enzyme (ACE) inhibition with captopril. The three neuropeptides increased nasal airway resistance (NAR) measured by anterior rhinomanometry and superficial capillary blood flow measured by laser Doppler flowmetry (LDF). After pretreatment of the nasal mucosa with PA, the effects of VIP, SP and CGRP on the LDF signal, NAR and mucus production were potentiated, whereas local pretreatment with captopril did not modify these functional effects. These observations suggest that NEP, but not ACE, may participate in the catabolism of neuropeptides when applied directly to the human nasal mucosa. Furthermore, since these neuropeptides induced nasal obstruction, increased blood flow and rhinorrhea, a decreased activity of the enzymes involved in their degradation could be involved in the physiopathology of rhinitis symptoms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00168025
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...