ISSN:
1432-2013
Keywords:
Endothelium
;
arteries
;
contractility
;
pH
;
hypercapnia
;
nitric oxide
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Hypercapnia induces initial constriction and prolonged relaxation of rat small mesenteric arteries. The mechanism of the relaxation is unknown, but has been attributed to lowering of pHi in the vascular smooth muscle. In this study we have investigated the response to raised PCO2 at constant pHo, in mesenteric small arteries precontracted with noradrenaline. 10% CO2 led to a fall in pHi associated with acute potentiation of tension, and subsequent relaxation. The relaxation did not occur in arteries in which the endothelium had been removed, nor in arteries pretreated with the nitric oxide synthase inhibitor, L-NAME (10−4M, NG-nitro-L-arginine methyl ester). The D-enantiomer, D-NAME, was without effect. We conclude that hypercapnic-induced vasodilatation in this circulation occurs via endothelium derived nitric oxide production.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00374415
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