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  • Digitale Medien  (4)
  • Aplasia  (2)
  • Engineering  (2)
  • 1
    Digitale Medien
    Digitale Medien
    Interleukin-6 (IL-6) levels in febrile children during maximal aplasia after bone marrow transplantation (BMT) are similar to those in children with normal hematopoiesis (1995)
    Springer
    Annals of hematology 70 (1995), S. 309-312 
    Details
    ISSN: 1432-0584
    Schlagwort(e): Key words Interleukin-6 ; Aplasia ; Bone marrow transplantation ; Hematopiesis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract  Interleukin-6 (IL-6) has been shown to be an inducer of the acute-phase response (APR) and to be involved in the pathogenesis of several disease states, including graft-versus-host disease (GvHD) following allogeneic bone marrow transplantation (BMT). As blood cells of the monocyte lineage are known to be major producers of this cytokine, we wondered whether extreme peripheral leukopenia following total ablation of hematopoiesis could compromise IL-6 production during the first days after allogeneic or autologous BMT. In the absence of detectable circulating leukocytes we measured elevated IL-6 levels in six children having fever (≥38°  C) of presumed infectious origin with an average of 74±60 units/ml (range 19–309 units/ml). IL-6 levels in febrile children having a normal hematopoiesis (118±254 units/ml, range 17–1213 units/ml) were not significantly higher than those found in the febrile BMT group (p〉0.05). Moreover, there was a clear association between elevated IL-6 levels and the presence of fever. C-reactive protein (CRP) was also elevated (≥1 mg/dl), whereas tumor-necrosis factor alpha (TNF) was undetectable (〈1 pg/ml). Two transplanted patients without fever during the period of total aplasia had neither detectable CRP nor IL-6, thus demonstrating that the transplant procedure itself does not induce an APR. Our data obtained during maximal leukopenia following BMT show that a functional hematopoietic system is not necessary for regular production of IL-6, which is associated with fever. Cells of nonhematopoietic origin may contribute to this production.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01696617
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Interleukin-6 (IL-6) levels in febrile children during maximal aplasia after bone marrow transplantation (BMT) are similar to those in children with normal hematopoiesis (1995)
    Springer
    Annals of hematology 70 (1995), S. 309-312 
    Details
    ISSN: 1432-0584
    Schlagwort(e): Interleukin-6 ; Aplasia ; Bone marrow transplantation ; Hematopiesis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Interleukin-6 (IL-6) has been shown to be an inducer of the acute-phase response (APR) and to be involved in the pathogenesis of several disease states, including graft-versus-host disease (GvHD) following allogeneic bone marrow transplantation (BMT). As blood cells of the monocyte lineage are known to be major producers of this cytokine, we wondered whether extreme peripheral leukopenia following total ablation of hematopoiesis could compromise IL-6 production during the first days after allogeneic or autologous BMT. In the absence of detectable circulating leukocytes we measured elevated IL-6 levels in six children having fever (≥38° C) of presumed infectious origin with an average of 74±60 units/ml (range 19–309 units/ml). IL-6 levels in febrile children having a normal hematopoiesis (118±254 units/ml, range 17–1213 units/ml) were not significantly higher than those found in the febrile BMT group (p〉0.05). Moreover, there was a clear association between elevated IL-6 levels and the presence of fever. C-reactive protein (CRP) was also elevated (≥1 mg/dl), whereas tumor-necrosis factor alpha (TNF) was undetectable (〈1 pg/ml). Two transplanted patients without fever during the period of total aplasia had neither detectable CRP nor IL-6, thus demonstrating that the transplant procedure itself does not induce an APR. Our data obtained during maximal leukopenia following BMT show that a functional hematopoietic system is not necessary for regular production of IL-6, which is associated with fever. Cells of nonhematopoietic origin may contribute to this production.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01696617
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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    Artikel (Nationallizenzen)
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  • 3
    Digitale Medien
    Digitale Medien
    Application of the finite element method to the simulation of sheet forming processes: Comparison of calculations and experiments (1990)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 30 (1990), S. 1415-1430 
    Details
    ISSN: 0029-5981
    Schlagwort(e): Engineering ; Engineering General
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Mathematik , Technik allgemein
    Notizen: Elastic-plastic finite element calculations have been carried out to analyse sheet forming processes such as hydrostatic bulging of circular and rectangular blanks and the axisymmetric stretching of sheets (with different punch radii). The results, partly obtained by different finite element models, are compared with experimental data. It could be shown that, regarding the examples considered, experiments and calculations fit well and that a more sophisticated modelling of the contact boundary conditions improves the accuracy of the results. As a first attempt to handle more complex sheet forming operations, the deep drawing of a rectangular cup has been analysed. A summary of the theoretical background as well as some comments on the solution method and the implementation are given.
    Zusätzliches Material: 15 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/nme.1620300806
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  • 4
    Digitale Medien
    Digitale Medien
    RECURSIVE MULTIDIMENSIONAL INTEGRATION (1997)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 40 (1997), S. 1923-1935 
    Details
    ISSN: 0029-5981
    Schlagwort(e): recursive autoadaptive multidimensional numerical integration ; Engineering ; Numerical Methods and Modeling
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Mathematik , Technik allgemein
    Notizen: This article introduces quadtree and octree like methods to numerical integration. Four recursive and auto-adaptive algorithms are presented: one for two-dimensional integrals over a triangular region, one for two-dimensional integrals over a quadrilateral region, one for three-dimensional integrals over a tetrahedral region and one for three-dimensional integrals over a cubic region. The algorithms have been proven to work fast. © 1997 John Wiley & Sons, Ltd.
    Zusätzliches Material: 11 Ill.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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