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  • 1
    ISSN: 1573-7217
    Keywords: aminoglutethimide ; breast cancer ; endocrine therapy ; medroxyprogesterone acetate ; tamoxifen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In order to evaluate the efficacy of two different sequences of second and third line hormonotherapy in advanced post-menopausal breast cancer, 257 women aged 36–91 years (mean age: 63.6 years) who had become resistant to tamoxifen (TAM), entered into a multicenter randomized trial comparing two different regimens: 1) Aminoglutethimide (Ag) 500 mg/day with hydrocortisone supplementation from 30 to 60 mg/day; and 2) oral medroxyprogesterone acetate (MPA) 500 mg twice a day. 250 patients were evaluated following second line hormone therapy and, after cross-over, 128 following third line hormonotherapy. No significant difference was observed, during either second or third line therapies, for toxicity, survival, or response rate; however, in both second and third line therapies the median time to progression was significantly longer with Ag therapy.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Electronic Resource
    Electronic Resource
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 22 (1996), S. 393-409 
    ISSN: 0271-2091
    Keywords: generalized Stokes problem ; Chebyshev spectral method ; thermosolutal convection ; directional solidification ; vertical Bridgman problem ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The paper presents a Chebyshev-Fourier collocation method for solving the unsteady 3D Navier-Stokes equations in a cylindrical domain. The numerical scheme uses primitive variables and the incompressibility constraint is satisfied by applying iteratively a correction to the pressure field. The method, due to Cahouët and Chabard (Int. j. numer. methods fluids,8, 869-895 (1988)) and originally developed in the framework of finite elements, is checked with respect to the present high-order approach. Several tests are carried out in Cartesian geometries, successively 2D and 3D, then a comparison is performed in a cylindrical domain with two different sets of radial collocation nodes: Gauss-Lobatto nodes and Gauss-Radau points. Although quite acceptable results are obtained with the latter chain, a general decrease in efficiency is noticeable in the collocation method. This is interpreted as the consequence of two factors: the collocation formulation is not symmetric and the Fourier analysis, used as heuristic guide by CahouMt and Chabard, loses its efficiency in a non-equidistant grid, especially in a cylindrical geometry.We present an application to the study of thermosolutal convection induced by unidirectional solidification of a binary alloy. The latter grows from a Pb-30%Tl liquid phase in a cylindrical crucible corresponding to the vertical Bridgman upward configuration. We study the influence of the flow patterns on the crystal composition.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
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