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  • 1
    Electronic Resource
    Electronic Resource
    Immunohistochemical localization of endothelin-1 in non-neoplastic and neoplastic adrenal gland tissue (1994)
    Springer
    Virchows Archiv 425 (1994), S. 259-264 
    Details
    ISSN: 1432-2307
    Keywords: Endothelin-1 ; Adrenal gland ; Adrenal tumour ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Endothelin (ET)-1 is a 21-amino acid peptide with potent vasopressor and vasocontrictive properties. Biochemical studies suggest that this peptide occurs in adrenal glands, where it influences steroid hormone production. However, we have found no report of the topographical distribution of this peptide. The localization of ET-1 immunoreactivity in non-neoplastic (37 cases) and neoplastic adrenal glands (48 cases) was investigated with a sensitive immunohistochemical technique applied to routinely processed tissue specimens. ET-1 immunoreactivity was regularly seen in the cortex, especially in the zona fasciculata and to a varying extent also in the other two zones, but not in the medulla. The immunoreactive material appeared in the cytoplasm mostly in the form of vacuolar structures but also as grains. Focally, the cell membrane also showed immunoreactive staining. In the zona reticularis the immunoreactivity appeared mainly as cytoplasmic grains. Most cortical adenomas displayed numerous immunoreactive cells. The immunoreactivity in the tumour tissue appeared in the same forms as in normal cortex, but the reactive products were generally fewer in number. No obvious differences in immunostaining were seen between the aldosterone- and cortisol-producing adenomas or the non-functioning ones. Three of the ten carcinomas contained immunoreactive cells, but they were few, appearing focally and the ET-1 immunoreactive structures were seen as ‘dust-like’ material. The difference in immunoreactivity between the benign and the malignant cortical neoplasms may be of diagnostic value. Functionally our results support a relationship between ET-1 and steroid regulation in non-neoplastic cortical tissue.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00196148
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Innervation of human adrenal gland and adrenal cortical lesions (1999)
    Springer
    Virchows Archiv 435 (1999), S. 580-589 
    Details
    ISSN: 1432-2307
    Keywords: Abstract Adrenal cortex ; Adrenal tumour ; Innervation ; Immunohistochemistry ; Neuronal markers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The innervation of the human adrenal gland and of cortical lesions was studied in sections of cortical tissue (n=10), hyperplastic cortical tissue (n=3), and tissue from cortical adenomas (n=5) and carcinomas (n=6). The presence and distribution of nerve structures containing neuronal markers indicating sympathetic and parasympathetic innervation were studied by immunohistochemistry and the co-existence and co-localization patterns of the different markers by immunofluorescence. The cortex and hyperplastic cortical tissue had a moderate to rich supply of nerve structures containing the typical neuronal markers: protein gene product 9.5 (PGP 9.5), neuron-specific enolase (NSE), small vesicle synaptic protein type 2 (SV2), and nerves showing immunoreactivity to the adrenergic marker tyrosine hydroxylase (TH). All these immunoreactive nerves were located predominantly adjacent to blood vessels, but also among parenchymal cells. The cortex showed numerous nerve structures containing the neuropeptide substance P (SP), neuropeptide Y (NPY) and vasoactive intestinal protein (VIP), but few nerves containing these peptides were seen in hyperplastic cortical tissue. Typical markers were occasionally observed in cortical adenomas but were not found in carcinomas, except in a few cases where PGP 9.5 and NSE were present, but only adjacent to necrotic areas. Nerves containing NPY and VIP occurred in varying numbers in both adenomas and carcinomas. NPY- and VIP-immunoreactive nerve structures were seen mostly alongside blood vessels. There were several types of co-existence. For instance, NSE/VIP-, TH/VIP- and TH/NPY-immunoreactive nerve structures were often seen in the same trunk, but were only partly co-localized.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004280050444
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  • 3
    Electronic Resource
    Electronic Resource
    A least-squares finite element method for time-dependent incompressible flows with thermal convection (1993)
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 17 (1993), S. 271-289 
    Details
    ISSN: 0271-2091
    Keywords: Least-squares finite element method ; Time-dependent ; Incompressible flows ; Bqussinesq approximation ; Navier-Stokes equations ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The time-dependent Navier-Stokes equations and the energy balance equation for an incompressible, constant property fluid in the Boussinesq approximation are solved by a least-squares finite element method based on a velocity-pressure-vorticity-temperature-heat-flux (u-P-ω-T-q) formulation discretized by backward finite differencing in time. The discretization scheme leads to the minimization of the residual in the l2-norm for each time step. Isoparametric bilinear quadrilateral elements and reduced integration are employed. Three examples, thermally driven cavity flow at Rayleigh numbers up to 106, lid-driven cavity flow at Reynolds numbers up to 104 and flow over a square obstacle at Reynolds number 200, are presented to validate the method.
    Additional Material: 12 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/fld.1650170402
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  • 4
    Electronic Resource
    Electronic Resource
    Transient solutions for three-dimensional lid-driven cavity flows by a least-squares finite element method (1995)
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 21 (1995), S. 413-432 
    Details
    ISSN: 0271-2091
    Keywords: least-squares finite element method ; Jacobi conjugate gradient method ; three-dimensional flows ; time-accurate solutions ; lid-driven flows ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: A time-accurate least-squares finite element method is used to simulate three-dimensional flows in a cubic cavity with a uniform moving top. The time- accurate solutions are obtained by the Crank-Nicolson method for time integration and Newton linearization for the convective terms with extensive linearization steps. A matrix-free algorithm of the Jacobi conjugate gradient method is used to solve the symmetric, positive definite linear system of equations. To show that the least-squares finite element method with the Jacobi conjugate gradient technique has promising potential to provide implicit, fully coupled and time-accurate solutions to large-scale three-dimensional fluid flows, we present results for three-dimensional lid-driven flows in a cubic cavity for Reynolds numbers up to 3200.
    Additional Material: 17 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/fld.1650210505
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    THREE-DIMENSIONAL TRANSIENT MOLD COOLING ANALYSIS BASED ON GALERKIN FINITE ELEMENT FORMULATION WITH A MATRIX-FREE CONJUGATE GRADIENT TECHNIQUE (1996)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 39 (1996), S. 3049-3064 
    Details
    ISSN: 0029-5981
    Keywords: mold cooling ; injection molding ; finite element method ; three-dimensional ; Jacobi conjugate gradient ; matrix-free algorithm ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: A methodology is presented to simulate the three-dimensional heat transfer within a mold during the injection molding process. The mold cooling analysis assists cooling channel design and paves the way for part shrinkage and warpage analysis. The transient temperature distributions in the mold and the polymer part are simultaneously computed by Galerkin Finite Element Method (GFEM) using a matrix-free Jacobi Conjugate Gradient (JCG) scheme. The numerical method presented here is efficient and has shown to require a fraction of the memory and computing time required by conventional methods. The matrix-free algorithm is initially validated using an injection mold designed to produce a plaque with a molded-in hole. Subsequently, the method is further applied to a representative automotive plastic component.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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    Paper (German National Licenses)
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