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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 42 (1992), S. 151-154 
    ISSN: 1432-1041
    Keywords: Antidiabetic drugs ; drug utilization ; health care systems ; Spain ; DDD
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The consumption of antidiabetic drugs in a Spanish region (Extremadura) in the period 1986–1987 has been investigated by the “defined daily dose” (DDD) method. The study was done in three health care systems in the region: civil servants (“Mutualidad de Funcionarios Civiles del Estado: MUFACE”) armed forces group (“Instituto Social de las Fuerzas Armadas: ISFAS”) and the national system (“Instituto Nacional de la Salud: INSALUD”). The total consumption of antidiabetic drugs varied three-fold, ranging from 5,73 DDD per 1000 inhabitants per day (3,71 DDD per 1000 inhabitants per day for oral antidiabetic drugs and 2,02 DDD per 1000 inhabitants per day for insulin) in the civil servant group to 15,82 DDD per 1000 inhabitants per day (12 DDD per 1000 inhabitants per day for oral antidiabetic drugs and 3,82 DDD per 1000 inhabitants per day for insulins) in the armed forces. The differences were more pronounced for oral antidiabetics than for insulins. The utilization of insulin among the civil servants was about half of that by the two other groups. Of oral antidiabetics, sulphonylureas were the most frequently used by the three groups, and within them glibenclamide accounted for more than half of the DDDs, while biguanides were scarcely used in any group. The differences are difficult to assess, since they could be due to several factors, such as age-differences in the population studied, different prescribing habits, and differences in sociocultural level. The results justify further comparative studies of drug utilization in different health systems within the same region.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 27 (1989), S. 501-522 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: We used a conjugate gradient type method, with preconditioning, to solve the sparse linear systems arising from the discretization of PDEs. With such methods, the main obstacles for complete vectorization have been the preconditioning calculation and its application step within the iteration: for the matrices obtained using 5- or 9-point discretization operators, some well known existing preconditionings (like ILU) require a block-recursive procedure which prevents vectorization. Preconditioners based on nested incomplete factorization, which require the calculation of approximate inverses of tridiagonal matrices, allow complete vectorization of the application step. We present a formulation of such a preconditioning, using a Frobenius norm minimization to calculate the inverses, which also allows complete vectorization of the inverses' calculation, thus making the iterative solver completely vectorizable. Numerical experiments show that the method is robust over a range of symmetric and non-symmetric problems, and up to 4 times faster than other existing methods, such as ILU, depending on the computer and compiler being used. We also show the importance of diagonal scaling used in conjunction with other preconditionings and present some theoretical results concerning the approximate inverses of tridiagonal matrices, calculated using the Frobenius norm minimization.
    Additional Material: 19 Ill.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Communications in Applied Numerical Methods 1 (1985), S. 263-267 
    ISSN: 0748-8025
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: Linear equations arising from reservoir simulation are closely coupled at the local-cell level, and the variables and equations tend to be poorly equilibrated. Scaling by the inverse of the diagonal block has an equilibrating effect. It usually improves the condition of the matrix for solution by linear iteration. The effects of block diagonal scaling are illustrated for a thermal reservoir simulator, where the original matrix may be indefinite. These results illustrate that for difficult problems block diagonal scaling can significantly enhance the convergence rate of the iterative method. It is also illustrated that preconditioned generated by block incomplete LU decomposition (ILU) and block symmetric Gauss Seidel (BSGS) methods are effective preconditioned for use in thermal simulation.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
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