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  • Engineering General  (4)
  • DNA  (2)
  • Estrogen  (2)
  • 1
    Digitale Medien
    Digitale Medien
    Identification of the estrogen sensitive marker in human endometrial carcinoma RL95-2 cells
    Amsterdam : Elsevier
    Molecular and Cellular Endocrinology 101 (1994), S. 167-171 
    Details
    ISSN: 0303-7207
    Schlagwort(e): Endometrium ; Estrogen ; Lactoferrin ; Oncogene ; RL95-2 cell ; c-fos ; c-myc
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Biologie , Medizin
    Materialart: Digitale Medien
    URL: http://linkinghub.elsevier.com/retrieve/pii/0303-7207(94)90231-3
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  • 2
    Digitale Medien
    Digitale Medien
    Modulation of hepatocyte growth factor gene expression by estrogen in mouse ovary
    Amsterdam : Elsevier
    Molecular and Cellular Endocrinology 104 (1994), S. 173-181 
    Details
    ISSN: 0303-7207
    Schlagwort(e): Estrogen ; Estrogen responsive element ; Gene expression ; Hepatocyte growth factor (HGF) ; Mouse ovary
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Biologie , Medizin
    Materialart: Digitale Medien
    URL: http://linkinghub.elsevier.com/retrieve/pii/0303-7207(94)90120-1
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  • 3
    Digitale Medien
    Digitale Medien
    Neuronal and glial DNA fragmentation in Pick’s disease (1999)
    Springer
    Acta neuropathologica 98 (1999), S. 55-61 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Key words Apoptosis ; Cell death ; DNA ; fragmentation ; Neurodegeneration ; Pick’s disease
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Pick’s disease (PD) is characterized by severe neuronal loss and gliosis in a frontotemporal lobar distribution, often associated with Pick bodies and ballooned neurons. Abnormal tau metabolism has been implicated in the pathogenesis of PD; however, the underlying mechanism of neuronal degeneration remains poorly understood. Evidence from other neurodegenerative diseases has suggested that DNA damage and apoptosis may play a major role in cellular degeneration and death. In the present study, an in situ nucleotidyl transferase assay (ISNTA) was used to identify DNA fragmentation in three cases of classical PD with Pick bodies and ballooned neurons, and two PD “variants”, one with ballooned neurons only and the other without Pick bodies or ballooned neurons. In all cases large numbers of ISNTA-positive neurons were present in anatomic regions having obvious degenerative changes (neuronal atrophy and loss, gliosis, cytoplasmic inclusions) by conventional histology. There was no clear association between neuronal DNA fragmentation and the presence of structural abnormalities such as Pick bodies or ballooned cytoplasm. ISNTA-positive glia were present in both cortex and subcortical white matter. Morphologic evidence of apoptosis was not detected in either neurons or glial cells. We suggest that DNA fragmentation in PD and probably other neurodegenerative disorders most likely specifies a population of potentially vulnerable cells in which both cell death and repair mechanisms have been activated. It is likely that only a very small number of these vulnerable cells at a given time will proceed to cell death; however, it is uncertain whether this occurs by apoptosis or some other mechanism.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s004010051051
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  • 4
    Digitale Medien
    Digitale Medien
    Capillary gel electrophoresis of nucleic acids in pluronic F127 copolymer liquid crystals (1999)
    Springer
    Chromatographia 49 (1999), S. S65 
    Details
    ISSN: 1612-1112
    Schlagwort(e): Review ; Capillary electrophoresis ; DNA ; Oligonucleotides ; Pluronic polymers ; Liquid crystals ; Micelles
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary The liquid crystalline gel phases of solutions of Pluronic F127, a triblock copolymer, were recently introduced as an alternative to disordered solutions of random coil polymers as replaceable media for capillary gel electrophoresis (CGE). Pluronic F127, from BASF, is a copolymer of poly(ethylene oxide) and poly(propylene oxide) with the approximate formula (EO)106 (PO)70 (EO)106. Polymer chains aggregate into spherical micelles in aqueous solutions, with poly(propylene oxide) chains creating a hydrophobic core surrounded by brushes of hydrated poly(ethylene oxide) tails. Crowding at high concentrations promotes ordering of micelles. Solutions in the range of about 14–24 % polymer are self-supporting, gel-like cubic liquid crystals at 25–30°C, but when cooled they become low viscosity liquids that are easily loaded into capillaries. This article reviews applications of Pluronic F127 media for capillary gel electrophoresis separations of nucleic acids of several types including oligonucleotides, double stranded DNA fragments, and supercoiled plasmid DNAs.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02468978
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  • 5
    Digitale Medien
    Digitale Medien
    Error estimates and convergence rates for various incompressible elements (1989)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 28 (1989), S. 2191-2202 
    Details
    ISSN: 0029-5981
    Schlagwort(e): Engineering ; Engineering General
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Mathematik , Technik allgemein
    Notizen: This note reports numerical experiments on the efficiency of simple error estimates derived earlier1 applied to incompressible mixed or related penalty type formulations. The rate of convergence and performance of various mixed elements is compared. Numerical results from a driven cavity and an incompressible elastic problem demonstrate that the T6B1/3D and T6/3C elements give a faster rate of convergence than the T6/1D element. However, in the case of a plane extrusion analysis (stronger singularity), the rate of convergence for the T6B1/3D element drops and is inferior to that of the T6/1D, while the T6/3C element still proves superior to the other two elements.
    Zusätzliches Material: 11 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/nme.1620280914
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  • 6
    Digitale Medien
    Digitale Medien
    Adaptive FEM computation of forming processes - Application to porous and non-porous materials (1990)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 30 (1990), S. 1527-1553 
    Details
    ISSN: 0029-5981
    Schlagwort(e): Engineering ; Engineering General
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Mathematik , Technik allgemein
    Notizen: This paper presents the ‘flow formulation’ approach applicable to both compressible and incompressible forming analysis. Appropriate error estimates and adaptive remeshing schemes are described for updated co-ordinate analysis. Several numerical examples are given. These are backward-forward extrusion and thermally coupled extrusion of pore-free materials, followed by cylinder upsetting, and tapered die extrusion of porous materials. The simulation of the deformation is shown as well as the distribution of effective strain and density at different time stages. The procedures are automatic and are incorporated in a general purpose code FEMMETA.
    Zusätzliches Material: 23 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/nme.1620300812
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  • 7
    Digitale Medien
    Digitale Medien
    Assessment of discretized errors and adaptive refinement with quadrilateral finite elements (1992)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 33 (1992), S. 781-798 
    Details
    ISSN: 0029-5981
    Schlagwort(e): Engineering ; Engineering General
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Mathematik , Technik allgemein
    Notizen: This paper studies discretized errors, and their estimation in conjunction with quadrilateral finite element meshes which are generated by the intelligent mesh generator XFORMQ.1 The exact energy error is used to evaluate the distortion effect of the quadrilateral mesh. The Zienkiewicz-Zhu2 error estimate and actaptive procedure are applied to the short cantilever and the square plate problems using the quadrilateral mesh generator XFORMQ. It is shown that the multistage quadrilateral element refinement produces results superior to the triangular element refinement in the test cases.
    Zusätzliches Material: 10 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/nme.1620330408
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  • 8
    Digitale Medien
    Digitale Medien
    Error estimation and adaptivity in flow formulation for forming problems (1988)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 25 (1988), S. 23-42 
    Details
    ISSN: 0029-5981
    Schlagwort(e): Engineering ; Engineering General
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Mathematik , Technik allgemein
    Notizen: A very simple and reliable error estimator has recently been developed for problems of linear elasticity.1 This leads naturally toa predication of an h-mesh refinement required for a given accuracy and with a suitable mesh generator2 for an efficient adaptive process. In this paper we extend the methodology developed previously to incompresible plastic flow of metals or polymers using the ‘flow formulation’ approach.3The examples of application include steady state extrusion problems for which exact solutions are available and hence allow the efficiency of the error estimates to be tested as well as more complex problems of upsetting in which the mesh is updated. It is found that the estimator performs well under various circumstances and provides an economical adaptive process.
    Zusätzliches Material: 19 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/nme.1620250105
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