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  • Cell & Developmental Biology  (2)
  • Engineering data management  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Engineering with computers 10 (1994), S. 1-11 
    ISSN: 1435-5663
    Keywords: CIM ; Case studies ; Engineering data management ; Information integration ; Integration framework ; Integration methodology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Technology
    Notes: Abstract Information integration is vital for keeping manufacturing operations competitive. A case study approach has been adopted to better understand the role of informatio in integrated manufacturing. Information is now considered a corporate asset. The creation, processing, movement and security of information is therefore as important as the products/services of an enterprise. The case studies have helped in identifying the requirements and issues involved in developing an information system and supporting software framework for a manufacturing enterprise. This paper deseribes a case study dealing with the integrated manufacture of optical fiber products. A phased development and implementation approach was adopted where a small, manageable slice of the system is considered for the case study followed by functional modeling (IDEFO) and data flow modeling (data flow diagrams). This identifies the pieces of information of interest. The information relationships are modeled using extended entity relationship (EER) diagrams which are then mapped to a relational model. The relational tables thus obtained were implemented on a commercial Database Management System (DBMS). The functional constraints and application interfaces were then built using Structured Query Languages (SQL) and commercial application interface tools. Subsequent sections describe the functional models, data flow diagrams (DFDs), EER diagrams, relational database design and user/application interfaces developed for the system. Implementation experiences and observations are discussed along with the applications of the implemented system. The case study has helped in developing a preliminary data model (i.e., a model about data by which a reasonable interpretation of the data can be obtained) for material handling (MH) functions.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 105 (1980), S. 163-180 
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: We have examined culture fluids from a variety of Kirsten murine sarcoma virus (KiMSV) transformed rat and mouse cells for the presence of factors which induce normal Rat-1 cells to assume the transformed phenotype. All KiMSV transformants produced transforming factor (TF). Revertants of KiMSV transformed rat or mouse cells failed to relase TF as did normal rat or mouse cells. Cells transformed by a temperature sensitive mutant of KiMSV produced TF at the permissive temperature but not at the nonpermissive temperature. Further, cells from a spontaneous transformant of Rat-1 cells also produced TF. TF is a small polypeptide which competes for the epidermal growth factor receptor. Its effect upon normal cells is reversible and requires de novo RNA and protein synthesis. Cells treated with TF lose the actin fibers observed in normal fibroblasts, assume a transformed cell morphology, become anchorage independent for growth, grow in low concentrations of serum, grow to a high cell density, and have an increased rate of hexose uptake.
    Additional Material: 12 Ill.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 110 (1982), S. 81-83 
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Reports from several laboratories have suggested that the virus transformed state may be maintained either by ectopically produced growth factors of alternatively by ectopically produced serine proteases including plasminogen activator. Here we show that the maintenance of transformation induced by Kirsten sarcoma virus induced growth factor(s) is independent of serine proteases in that (1) the factors are not themselves serine proteases, and (2) the growth factors do not induce the expression of detectable serine proteases or plasminogen activator.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
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