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A dose-dependent effect of recombinant erythropoietin on the reticulocyte population of rats (1989)

Eder, H. ; Roßlenbroich, B. ; Failing, K.

Springer

Annals of hematology 59 (1989), S. 184-187

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ISSN: 1432-0584

Keywords: Erythropoietin ; Stimulation of erythropoiesis ; Erythropoietin bioassay ; Reticulocytes

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary The effect of human recombinant erythropoietin (rEPO) on the reticulocyte count and the reticulocyte maturation distribution in rats was measured with an automatic reticulocyte analysis system (AURAS). The strongest reaction was found on the third day after a single application of rEPO with respect to reticulocyte count, maturation distribution, and the count of immature reticulocytes. At this time these parameters show a distinct dose dependency. The results indicate a possible basis for a simple rEPO bioassay using normocytemic rats.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00320065

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