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  • 1
    Electronic Resource
    Electronic Resource
    Untersuchungen zur Thrombozytenfunktion bei essentieller Thrombozythämie und reaktiver Thrombozytose (1988)
    Springer
    Journal of molecular medicine 66 (1988), S. 199-207 
    Details
    ISSN: 1432-1440
    Keywords: Essential thrombocythemia ; Platelet aggregation studies in essential thrombocythemia ; Epinephrine-induced platelet aggregation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Blood of 16 patients with essential thrombocythemia (ET), 9 patients with reactive thrombocytosis (RT) and 13 healthy persons was used for platelet aggregation studies. When the aggregation was induced with adenosine diphosphate (0.01 µM), collagen (0.1 µg/ml) or platelet activating factor (PAF 0.5 µM) the plasma of the patients with ET showed significantly decreased aggregation (35%–44% of the value for the control groups). Independent of inhibitors of platelet aggregation, thrombin (0.05 U/ml) caused similar aggregation in healthy controls and patients with ET; patients with RT showed an increased aggregation. Adrenalin-induced aggregation discriminated best between patients with ET and controls. Adrenalin in concentrations ranging from 0.01 µg/ml to 100 µg/ml caused comparable dose-related amounts of aggregation in healthy controls and patients with RT. Over the whole concentration range, patients with ET showed significantly decreased aggregation (28%–34% of the value for the control groups). This difference proved to be independent of the influence of inhibitors of platelet aggregation. Though concentrations of alpha1-acid glycoprotein never reached inhibitory levels in the plasma of patients with ET (n=12) they were significantly higher compared with those in normal plasma (n=12). Fibrinogen concentrations in plasma of ET-patients (n=12) were in the normal range. Cellular adenosine 3′–5′-cyclic monophosphate concentrations in ET (n=10) are comparable with normal values (n=5). The significance of the results for diagnosis and better pathophysiological understanding of ET is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01728197
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Relapsing acute febrile neutrophilic dermatosis and essential thrombocythemia (1984)
    Springer
    Annals of hematology 48 (1984), S. 297-305 
    Details
    ISSN: 1432-0584
    Keywords: Acute febrile neutrophilic dermatosis ; Essential thrombocythemia ; Sweet's syndrome ; Paraneoplastic disorder
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Relapsing acute febrile neutrophilic dermatosis (AFND) is reported in a patient with essential thrombocythemia representing the first case of this kind described in the literature. The patient presented with fever, malaise, neutrophilic leukocytosis, dysproteinemia, and coalescing bluish-red painful plaques and papules at palms, forehead, lid, forearm, and thigh. There was a dramatic response to steroids, or indomethacin, with no scarring. AFND was preceded by sore throat and an upper respiratory infection and was accompanied by conjunctivitis and arthritis of knees and ankle-joint. The association of AFND with essential thrombocythemia and with other neoplastic disorders is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320401
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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