Electronic Resource
Springer
Pediatric surgery international
2 (1987), S. 132-141
ISSN:
1437-9813
Keywords:
Cryptorchidism
;
Etiology treatment
;
Histology
;
Fertility
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Cryptorchidism represents a disease of the hypothalomo-pituitary-gonadal axis and is not a malformation. Early treatment (10 months of age) should be started to avoid infertility, which often occurs. The lower the testes are situated, the better their histology; the younger the children are, the more normal their gonads. During the first month of life the important transformation of gonocytes into spermatogonia takes place. This transformation is gonadotropin and testosterone-dependent and is impaired in cryptorchid boys. After the second year of life 38% of cryptorchid boys completely lack germ cells. This group of patients is at risk of developing sterility. Standard treatment with LH-RH and HCG was successful in 74% of all boys treated. In the boys in the group at risk, 6 months of low-dose buserelin treatment significantly improved the number of the germ cells. This mode of treatment may improve the prognosis of fertility and completely open new fields in the treatment of undescended testes.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00185138
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