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  • 1
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Magnetresonanztomographie ; MRT ; Haut ; In-vivo-Histometrie ; Tumore ; Keywords MRT ; Skin ; Thickness ; Dermatology ; Tumors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Purpose: To characterize human skin qualitatively and quantitatively using high-resolution magnetic resonance tomography (MRT) and to compare skin thickness measurements from MRT and histological specimens. Material and Methods: The skin of 84 persons was examined by use of a 2.5 cm coil in a whole-body tomography (gradient field strength 1.5 T) at a linear resolution of 100 μm. To evaluate the ability to identify various skin structures, following an initial visual description, the signal-noise and contrast-noise ratios were analyzed and the MRT-image compared to the corresponding histological specimen. Results: Using the high-resolution coil, epidermis, dermis and subcutis were discernible. Problem areas included the cheek, distal leg and foot. Reproducible measuring of skin thickness with MRT is possible, but it does not correlate well with conventional histologic measurements.
    Notes: Zusammenfassung Ziel: Anhand von In-vivo-Untersuchungen war die Schnittbildanatomie der Haut hinsichtlich ihrer bislang unbekannten Erscheinung im hochauflösenden Magnetresonanztomogramm (MRT) zunächst qualitativ und quantitativ zu charakterisieren. Anschließend sollte der Wert der MRT hinsichtlich der Hautdickenmessung anhand eines Vergleiches mit histologischen Schnitten analysiert werden. Methodik: In einer prospektiven Studie wurde die Haut von 84 Personen mit Hilfe eines 2,5 cm großen Spulenkopfes in einem Ganzkörpertomographen (Gradientenfeldstärke: 1,5 T) bei einer linearen Auflösung von 100 μm untersucht. Zur Bewertung der Abgrenzbarkeit verschiedener Hautstrukturen wurden nach visueller Charakterisierung deren Signal-Rausch- und deren Kontrast-Rausch-Verhältnisse objektiviert und ein Vergleich mit histologischen Präparaten vorgenommen. Ergebnisse: Mit der Hochauflösungsspule lassen sich Epidermis, Dermis und Subkutis differenzieren (p〈0,05). Problematisch ist dies nur an Wange, distalem Unterschenkel und Fuß. Hautdickenmessungen mit der MRT sind zuverlässig möglich. Die Ergebnisse korrelieren aber nicht mit jenen der Histologie.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1619-7089
    Keywords: Technetium-99m sestamibi ; Tracer washout ; Tracer redistribution ; Exercise studies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aim of this study was to assess whether a clinically relevant change in myocardial sestamibi activity could be documented within the first 120 min following injection (p.i.). In 17 patients planar anterior imaging of the heart was performed 5 min and 120 min p.i. During this time interval, mean decay-corrected myocardial activity declined to 77.9%±9.7% after stress and to 85.7%±7.9% after injection at rest (P〈0.05). In 19 patients with angiographically documented coronary artery disease, single-photon emission tomography was performed 5 min and 120 min after injection at maximum stress. For analysis, sestamibi activity was scored semiquantitatively in six left ventricular segments. Furthermore, sestamibi uptake was assessed quantitatively using a circumferential profile method. In 35 of 114 segments the score improved within 120 min p.i. (early fillin); in these segments relative sestamibi activity rose from 69.9%±22.5% to 74.5%±20.8% (P〈0.01). In five patients this early fill-in was the only sign of exercise-induced hypoperfusion. In 7 of 114 segments the score deteriorated 120 min p.i. (early tracer washout); in these segments relative sestamibi activity declined from 85.6%±9.9% to 80.1%±10.7% (P〈0.02). In three of four patients with early tracer washout the corresponding coronary artery was significantly narrowed. In conclusion, a global myocardial sestamibi washout was registered within the first 120 min after injection. A fill-in of initial defects as well as an early tracer loss could be detected in a relevant number of patients with chronic coronary artery disease during the first 2 h p.i. In these patients the extent of detected reversible perfusion abnormality depends on the chosen time interval between injection and imaging. The results of this study suggest that exercise imaging should be started immediately after injection.
    Type of Medium: Electronic Resource
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