ISSN:
1432-1246
Keywords:
Ethylbenzene
;
Exposure test
;
Mandelic acid
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Absorption of ethylbenzene and excretion of mandelic acid were investigated under controlled conditions in six volunteers, exposed at concentrations of 18, 34, 80, and 200 mg/m3. Retention of ethylbenzene vapours in the lungs was 49 ± 5%. Elimination of mandelic acid was found to be biphasic, with biological half-life values of 3.1 and 24.5 h. Total excreted mandelic acid accounts for 55 ± 2% of retained ethylbenzene. The results obtained were applied to devise an exposure test for ethylbenzene, which would enable the precise evaluation of exposure at low ethylbenzene, vapour concentrations (± 13%). Exposures, carried out dermally, gave a rationale for the exclusion of the skin as a route of entry of ethylbenzene vapours into the body.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00378068
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