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  • 1
    Electronic Resource
    Electronic Resource
    Fatal cerebral hemorrhage associated with cyclosporin-A/FK506-related encephalopathy after allogeneic bone marrow transplantation (2000)
    Springer
    Annals of hematology 79 (2000), S. 588-592 
    Details
    ISSN: 1432-0584
    Keywords: Key words Bone marrow transplantation ; Cerebral hemorrhage ; Cyclosporin A ; Encephalopathy ; FK506
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  We report a case of cerebral hemorrhage associated with cyclosporin A (CsA)/FK506-related encephalopathy that developed in a 16-year-old woman after allogeneic bone marrow transplantation. Hematopoietic engraftment occurred on day 15, and the patient developed systemic convulsions after CsA was replaced by FK506 for the treatment of acute graft-versus-host disease (GVHD). Based on magnetic resonance imaging, laboratory findings and cerebrospinal fluid studies, she was diagnosed as having CsA/FK506-related encephalopathy with cerebral hemorrhagic infarction. Although she recovered completely after discontinuation of FK506, she developed convulsions again 15 days after re-administration of FK506. A computed tomography scan showed cerebral hemorrhage. She died of respiratory failure. Vascular damage induced by immunosuppressive drugs and enhanced by acute GVHD seemed to be the cause of the cerebral hemorrhage. Since hypertension, which was present during both of the central nervous system events, seemed to have contributed to the development of the cerebral hemorrhage, it is proposed that CsA and FK506 should be reduced or discontinued when patients who have risk factors of hypertension become hypertensive even if they have no symptoms of neurotoxicity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002770000192
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Magnet designs for a crystal-lattice quantum computer (2000)
    Springer
    Applied physics 71 (2000), S. 11-17 
    Details
    ISSN: 1432-0630
    Keywords: PACS: 03.67.Lx; 76.60.Pc; 85.70.w
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract. A quantum computer using nuclear spins in a crystal lattice requires a method for addressing individual quantum bits. This identification can be achieved with a spatially varying magnetic field. Spins at different lattice sites can have distinguishable Zeeman frequencies allowing initialization, logic operations, and measurements to be performed through radio frequency (rf) pulse techniques. Here, we present magnet designs that have gradients between 1 and 20 T/μm, which are necessary to realize quantum computation with particular crystals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003390050018
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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