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  • 1
    Digitale Medien
    Digitale Medien
    Springer
    Virchows Archiv 426 (1995), S. 523-528 
    ISSN: 1432-2307
    Schlagwort(e): Von Hippel-Lindau disease ; Neuroendocrine tumour ; Electron microscopy ; Flow cytometry ; Immunohistochemistry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract A 21-year-old woman with a family history of von Hippel-Lindau disease presented with a mass in the head of the pancreas. Light microscopic features of the tumour suggested neuroendocrine differentiation and although it displayed positive immunostaining for the antigens expected in a neuroendocrine neoplasm, S-100 staining was also present. This unusual feature prompted further evaluation by routine and post-embedding protein-A gold immunoelectron microscopy, which demonstrated the presence of neuroendocrine granules. Tumour cell DNA content was normal by flow cytometry. Although this patient exhibited no other signs of von Hippel-Lindau disease, the presence of a pancreatic tumour with neuroendocrine differentiation demonstrated that she was affected. Future surveillance and genetic counselling will be influenced by this diagnosis.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Springer
    European journal of epidemiology 6 (1990), S. 55-60 
    ISSN: 1573-7284
    Schlagwort(e): Dietary variability ; Fat intake
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract An impediment to analyzing the effect of nutritional factors on biologic processes or health status in human populations arises from the relatively small dietary differences that exist between individuals in relation to large periodic fluctuations in dietary intake and the imprecision with which diet is normally assessed. We report here on characteristics of dietary variability in a group of 14 young men who successfully completed an intervention study specifically designed to create large differences in fat intake between baseline and two dietary intervention-periods each lasting two months (during which safflower and coconut oil supplements were given). We found that in the second supplemental phase of the intervention inter-person sources of variability were greatly increased over the low-fat baseline values. For proportion of calories as fat it increased to 64.2% of total variance from 21.6% without supplementation; for saturated fatty acids, 47.3% from 17.7%; for polyunsaturated fatty acids, 62.4% from 22.8%; and for the P:S ratio, 71.5% from 21.6%. During the first intervention phase we observed only moderate changes. Reasons for the intervention phase differences in effect, implications for feeding trials designed to look at dietary fat effects, and the need for future studies aimed at clarifying these results are discussed.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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