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  • 1
    Electronic Resource
    Electronic Resource
    Determination of fenfluramine enantiomers in pharmaceutical formulations by capillary zone electrophoresis (1995)
    Springer
    Chromatographia 41 (1995), S. 383-388 
    Details
    ISSN: 1612-1112
    Keywords: Capillary electrophoresis ; Enantiomer separation ; Cyclodextrins ; Pharmaceuticals ; Fenfluramine isomers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary Capillary zone electrophoresis has been used for the enantiomeric separation of racemic ortho-fenfluramine and meta-fenfluramine employing a phosphate buffer at pH 2.5 added with cyclodextrins. The cyclodextrin type and concentration strongly influenced the chiral resolution. The uncharged β-cyclodextrin polymer gave enantiomeric resolution of both ortho and meta isomers, while γ-cyclodextrin was a good chiral selector for only ortho-fenfluramine; heptakis-2,3,6-tri-O-methyl-β-cyclodextrin permitted base line separation of meta-fenfluramine enantiomers but only partial resolution of racemic ortho-fenfluramine. The optimized electrophoretic method was applied to the quantitative analysis of 1-meta-fenfluramine (minor component in the mixture) and d-meta-fenfluramine in a commercial pharmaceutical formulation. Good reproducibility for migration time and corrected peak areas (R.S.D. 〈0.8% and 〈1.2%, respectively) was achieved and the presence of the minor component of the mixture was found to be in accord to previous determinations performed by other analytical methods.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02318609
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  • 2
    Electronic Resource
    Electronic Resource
    Chiral discrimination and antipicornavirus activity of 6-oxazolinylisoflavan (1993)
    New York, NY [u.a.] : Wiley-Blackwell
    Chirality 5 (1993), S. 356-358 
    Details
    ISSN: 0899-0042
    Keywords: optical resolution ; chiral HPLC ; chiral stationary phase ; 6-oxazolinylisoflavan ; circular dichroism ; antipicornavirus activity ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Racemic 6-oxazolinylisoflavan, a highly effective inhibitor of rhinovirus serotype 1B in vitro, was resolved by high-performance liquid chromatography on a chiral stationary phase in order to study the activity of the enantiomers against picornaviruses. The absolute configuration of the two isomers was determined by circular dichroism curves. The antipicornavirus activity of each isomer, separately collected, was evaluated in vitro against human rhinovirus serotype 1B, enterovirus 71, echovirus 6, coxsackievirus B4, and poliovirus type 2 by means of the plaque reduction assay. Both enantiomers were inhibitors of picornavirus replication with the degree of their activity depending on virus and isomer tested. © 1993 Wiley-Liss, Inc.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/chir.530050515
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    Paper (German National Licenses)
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