ISSN:
1431-4630
Keywords:
Key words Sulphadimidine
;
Fermented sausage
;
Carbon-14-labelling
;
Rat
;
Bound residues
Source:
Springer Online Journal Archives 1860-2000
Topics:
Process Engineering, Biotechnology, Nutrition Technology
Notes:
Abstract Sulphadimidine (SDM), a drug frequently administered to pigs, is partially converted into other compounds by processing meat to produce raw, fermented sausage. With the aid of 14C-labelled SDM, evidence was obtained that part of the radioactive matter was covalently bound to the matrix. Part of these bound residues could be released in vitro by 4 M HCl at 21 °C or by 0.024 M HCl at 37 °C. Female rats were also able to release bound SDM residues and to excrete these in their urine, in amounts approaching those obtained by treatment with 4 M HCl. Both the parent compound and its main metabolite, N 4-acetyl-SDM, were observed in the urine of rats.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002170050399
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