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  • Electronic Resource  (6)
  • Cell & Developmental Biology  (3)
  • Ferrocyanide Method  (3)
  • 1
    Electronic Resource
    Electronic Resource
    The effect of antidiuretic hormone on the distribution of nephron filtration rates in rats with hereditary diabetes insipidus (1971)
    Springer
    Pflügers Archiv 330 (1971), S. 323-334 
    Details
    ISSN: 1432-2013
    Keywords: Nephron Filtration Rate ; Antidiuretic Hormone ; Diabetes Insipidus Rats ; Ferrocyanide Method
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of antidiuretic hormone on the distribution of nephron filtration rates was studied in rats with hereditary diabetes insipidus using the Hanssen method for determination of nephron filtration rates as modified by de Rouffignacet al. [18]. Conversion of water diuresis to antidiuresis by infusion of ADH resulted in a moderate, but highly significant increase in the filtration rate of the juxtamedullary nephrons, while the nephrons of all other cortex regions filtered at an unaltered rate. A mechanism based on the action of ADH on distal nephron water permeability is proposed as an explanation: water inflow into the medulla very likely decreases when water diuresis is converted to antidiuresis. This occasions a rise in medullary osmolality which then causes an increase in the apparent viscosity of the blood flowing through the vasa recta. This is responsible for a rise in juxtamedullary postglomerular resistance which results in an increase in the effective filtration pressure and thus in the juxtamedullary nephron filtration rate. The results suggest that an increased juxtamedullary filtration rate participates in the establishment and maintenance of the inner medullary solute gradients, possibly as a consequence of an increased solute delivery to the ascending limbs of the long loops of Henle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00588584
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Relationship between salt loading and distribution of nephron filtration rates in the dog (1974)
    Springer
    Pflügers Archiv 350 (1974), S. 259-272 
    Details
    ISSN: 1432-2013
    Keywords: Dog Kidney ; Saline Infusion ; Nephron Filtration Rate ; Filtrate Distribution ; Ferrocyanide Method
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The intrarenal distribution of nephron filtration rate (N-GFR) was assessed using the Hanssen ferrocyanide technique in dogs which were chronically salt loaded with or without an additional acute sodium load and in sodium depleted dogs. In 4 dogs fed 7–10 days on a high sodium diet, superficial nephron filtration rate (SN-GFR) was 56.7±13.1 nl/min, middle nephron filtration rate (MN-GFR) was 65.2±14.3 nl/min, and the juxtamedullary nephron filtration rate (JN-GFR) was 82.4±17.1 nl/min, a value 52.3% higher than the SN-GFR. Creatinine clearance in these animals averaged 22.0±3.9 ml/min. In 4 animals which received an additional infusion of 0.9% NaCl at 4.0–4.5 ml/min for 2.5 h, the mean creatinine clearance rose from 16.6±2.0 ml/min to 20.3±0.7 ml/min and the distribution of N-GFR was: SN-GFR 70.5±21.2 nl/min, MN-GFR 83.6±23.8 nl/min and JN-GFR 91.2±24.3 nl/min. In this case, the JN-GFR was 29.3% higher than the SN-GFR. In one sodium depleted dog, (creatinine clearance 15.7 ml/min) the distribution of N-GFR was: SN-GFR 41.1±10.5 nl/min, MN-GFR 48.0±16.5 nl/min, and JN-GFR 58.0±19.0 nl/min, a value exceeding SN-GFR by 41.1%. These results imply that acute saline infusion in dogs induces a proportionately greater change in GFR of superficial than of juxtamedullary nephrons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00587805
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  • 3
    Electronic Resource
    Electronic Resource
    The effect of experimental alterations in urine concentration on nephron filtration rate (1973)
    Springer
    Pflügers Archiv 344 (1973), S. 69-74 
    Details
    ISSN: 1432-2013
    Keywords: Nephron Filtration Rate ; Ferrocyanide Method ; Redistribution of GFR ; Urine Osmolarity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Experiments were performed to clarify the cause of the dependency of juxtamedullary nephron filtration rate (JN-GFR) on the diuretic state of the animal. Using the ferrocyanide technique of de Rouffignacet. al. [5] the distribution of nephron filtration rates was determined during selective modification of final urine osmolarity by papillary superfusion with concentrated or isotonic solutions. Papillary superfusion with a 2000 mosmolar solution led to a mean urine osmolarity of 1848±78 mOsm/l. JN-GFR displayed a mean increase of 66.6% over the superficial nephron filtration rate (SN-GFR). When the superfusion fluid was isotonic urine osmolarity averaged 754±53 mOsm/l and JN-GFR increased by a mean of only 26.3% over the SN-GFR. Using the micropuncture technique it was shown that SN-GFR in a given animal was not altered when the superfusion fluid was interchanged. We conclude therefore that the change in the percentage increase in GFR from superficial to juxtamedullary nephrons is caused by a change of juxtamedullary nephron filtration rate. Since plasma ADH concentration was not altered this effect appears to be elicited by the changed medullary solute concentration rather than by a vasomotor action of the antidiuretic hormone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00587442
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  • 4
    Electronic Resource
    Electronic Resource
    Mean weights of chick embryos correlated with the stages of Hamburger and Hamilton (1968)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 124 (1968), S. 79-82 
    Details
    ISSN: 0362-2525
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: A total of 1125 normal chick embryos, representing 25 each of the 45 stages of Hamburger and Hamilton, were removed, fixed in Bouin's solution, stored in 70% ethanol and weighed with a semi-micro analytical balance. Entire blastoderms of stages 1-8 were weighed, whereas only embryos-proper were weighed in stages 9-45. As a consequence, results constituted two groups, each of which showed a geometric rate of growth marked only by minor deviations which were related to specific events of normal growth and development.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jmor.1051240105
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  • 5
    Electronic Resource
    Electronic Resource
    The effects of prolonged low level radiation on the Coronary vessels of the developing chick embryoThis study was supported by a grant from the North Carolina Heart Association. (1968)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 161 (1968), S. 247-252 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Microcurie amounts of p32, Na22, Fe59, and Cl36 in normally occurring compounds were injected directly into the vitelline vessels of developing chick embryos at stage 24 (Hamburger and Hamilton, '51). The surviving embryos were sacrificed at stage 41. Hearts were removed and examined intact or sectioned for later examination. Coronary vessels were identified, classified according to size (large, diameter = 〉 80 μ; medium, diameter = 40-80 μ; small, diameter 〈 40 μ) and counted. There was a significant increase in the numbers of small and medium vessels which had developed in the presence of gamma radiation emitted by Na22- and Fe59-compounds. The p32- and Cl36-containing compounds did not affect the numbers of vessels of any size. The resulting increased vascularity is shown to be a matter of a distinct increase in numbers of blood vessels as opposed to a simple alteration of the normally occurring vessels.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091610209
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  • 6
    Electronic Resource
    Electronic Resource
    Uterine bleeding in spinal monkeysThis study was conducted with the aid of a grant from the sex division of the National Research Council and the Rockefeller Foundation Grant for FIuid Research in the Medical Sciences at Stanford University. (1936)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 64 (1936), S. 231-245 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1090640210
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