ISSN:
1432-2013
Keywords:
Dog Kidney
;
Saline Infusion
;
Nephron Filtration Rate
;
Filtrate Distribution
;
Ferrocyanide Method
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The intrarenal distribution of nephron filtration rate (N-GFR) was assessed using the Hanssen ferrocyanide technique in dogs which were chronically salt loaded with or without an additional acute sodium load and in sodium depleted dogs. In 4 dogs fed 7–10 days on a high sodium diet, superficial nephron filtration rate (SN-GFR) was 56.7±13.1 nl/min, middle nephron filtration rate (MN-GFR) was 65.2±14.3 nl/min, and the juxtamedullary nephron filtration rate (JN-GFR) was 82.4±17.1 nl/min, a value 52.3% higher than the SN-GFR. Creatinine clearance in these animals averaged 22.0±3.9 ml/min. In 4 animals which received an additional infusion of 0.9% NaCl at 4.0–4.5 ml/min for 2.5 h, the mean creatinine clearance rose from 16.6±2.0 ml/min to 20.3±0.7 ml/min and the distribution of N-GFR was: SN-GFR 70.5±21.2 nl/min, MN-GFR 83.6±23.8 nl/min and JN-GFR 91.2±24.3 nl/min. In this case, the JN-GFR was 29.3% higher than the SN-GFR. In one sodium depleted dog, (creatinine clearance 15.7 ml/min) the distribution of N-GFR was: SN-GFR 41.1±10.5 nl/min, MN-GFR 48.0±16.5 nl/min, and JN-GFR 58.0±19.0 nl/min, a value exceeding SN-GFR by 41.1%. These results imply that acute saline infusion in dogs induces a proportionately greater change in GFR of superficial than of juxtamedullary nephrons.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00587805
Permalink
