ISSN:
1434-4726
Keywords:
Key words Sinus mucosa
;
Chronic sinusitis
;
Fibrinolytic enzymes
;
Urokinase-type plasminogen
;
activator
;
Plasminogen activator inhibitor-1
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract We examined the effect of pH on the extraction of urokinase-type plasminogen activator (u-PA) and plasminogen activator inhibitor-1 (PAI-1) from paranasal sinus mucous membrane associated with chronic sinusitis and antrochoanal polyps. The specific activity of u-PA extracted with buffer at pH 7.4 was stronger than that extracted with buffer at pH 4.2. The antigen level of u-PA extracted with the acidic buffer was significantly higher than that extracted with the neutral buffer. In contrast, the difference in antigen levels of PAI-1 extracted with the acidic buffer and neutral buffer was not significant. Based on these results, we inferred that the u-PA-PAI-1 complex was extracted by the acidic buffer and the activity of u-PA was therefore decreased.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s004050050149
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