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  • 1
    Electronic Resource
    Electronic Resource
    Rapid quantitative analysis of morphine in blood by flash-heater methylation and gas chromatography with a nitrogen-specific detector (1986)
    Springer
    Chromatographia 22 (1986), S. 303-306 
    Details
    ISSN: 1612-1112
    Keywords: Gas chromatography ; Nitrogen-selective detector ; Flash methylation ; Morphine ; Blood analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary A simplified gas chromatographic method for the rapid determination of morphinn in rat and human blood is described. After single extraction, morphine was reconstituded in trimethylanilinium hydroxide and introduced directly into a gas chromatograph equipped with a nitrogen specific flame ionization detector. Limits of detection were 0.5μg/ml for either water or blood solutions. Analytical recoveries of morphine, added to either water or blood were 88±6 and 90±3% $$(\bar x \pm SD)$$ , respectively, when compared with morphine dissolved in methanol. The between-run coefficients of variation were 5.0 and 5.4% for water and blood, respectively, over the range of 0.5–32.2μg/ml, whereas the within-run coefficients of variation at 1μg/ml were 8.1 and 7.9%, respectively. The application of the method to an in vivo animal experiment is demonstrated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02268779
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Rapid and sensitive gas chromatographic method for detection of barbital and pentobarbital in blood using flash-heater methylation and nitrogen-specific detection (1987)
    Springer
    Chromatographia 23 (1987), S. 269-272 
    Details
    ISSN: 1612-1112
    Keywords: Gas chromatography ; Nitrogen-specific detector ; Flash methylation ; Barbital and pentobarbital ; Blood analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary A sensitive and simplified method is described for the determination of barbital (B) and pentobarbital (PB) in blood using gas chromatography with a nitrogen-specific flame ionization detector. After a simple one-step extraction, B and PB were reconstituted in trimethylanilinium hydroxide and introduced directly into the gas chromatograph. Lower limits of detection was 0.14 μg/ml for B and PB in either water or blood solutions. The recoveries for B from water and blood were 90 and 88%, respectively; for PB they were essentially complete. The average between-run and within-run coefficients of variation for B from water and blood were lower than 7.8%, whereas those of PB were lower than 3.0%. The scale and sensitivity of detection for B and PB were found to be suitable for use in pharmacokinetic studies in the rat.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02311778
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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