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  • 1
    Electronic Resource
    Electronic Resource
    Pharmacological studies of the rabbit and human renal pelvis (1974)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 285 (1974), S. 209-222 
    Details
    ISSN: 1432-1912
    Keywords: Renal Pelvis Smooth Muscle ; Sympathomimetic Amines ; Transmural and Periarterial Stimulation ; α-adrenoceptors ; Adrenergic Blocking Agents ; Fluorescence Histochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The responses of the isolated rabbit and human renal pelvis to drugs and to electrical stimulation have been investigated. Regular spontaneous changes in tension occur in the circular smooth muscle, which in the rabbit are synchronous with electrical waves. The responses to electrical stimulation seem to be due to the release of catecholamines from adrenergic nerves. Such nerves have been observed by means of a fluorescence technique. The cholinergic system appears functionally unimportant. The adrenergic responses in human and rabbit seem to be mediated exclusively by α-adrenoceptors. The denervated rabbit organ shows hypersensitivity, mainly to low concentrations of adrenaline. The failure of uptake inhibitors to potentiate the responses to noradrenaline seems in favour of postsynaptic hypersensitivity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00498991
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The time course of functional and morphological changes of the guinea-pig colon after “a frigore” denervation of the periarterial sympathetic nerves (1972)
    Springer
    Acta neuropathologica 22 (1972), S. 190-199 
    Details
    ISSN: 1432-0533
    Keywords: Fluorescence Histochemistry ; Sympathetic Denervation ; Periarterial Nerve Stimulation ; Regenerating Adrenergic Nerves
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary After sympathetic denervation of the guinea-pig distal colon the time course and the relationship between morphological and functional changes were studied, by using the fluorescence method and by evaluating the response of longitudinal muscle to periarterial nerve stimulation. The inhibitory response to sympathetic nerve stimulation was completely abolished 48 h after denervation. Tissue catecholamines can no longer be detected in either the intramural vessels or in the intramural plexuses 96 h after denervation, and in no preparation could they be observed again until 24 days after denervation. After 30 days catecholamines stores slowly began to reappear and were completely restored only 100–120 days after denervation. During the whole period of reinnervation the response to periarterial nerve stimulation was lacking. The inhibitory effect could be elicited only 130 days after denervation and before the morphological pattern had been completely restored.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00684522
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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