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  • 1
    Electronic Resource
    Electronic Resource
    Influence of the membrane stabilizer diphenylhydantion on potassium and sodium movements in skeletal muscle (1975)
    Springer
    Pflügers Archiv 358 (1975), S. 275-288 
    Details
    ISSN: 1432-2013
    Keywords: Skeletal Muscle ; Electrolytes ; Potassium ; Sodium ; Flux Inhibition ; Membrane Stabilization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The membrane stabilizer diphenylhydantoin (DPH) did not alter the net content of Na, K, Ca or Mg in frog sartorius muscle freshly incubated or actively transporting Na and K following Na-loading and K-depletion. Resting influx of K from normal Ringer was significantly reduced by DPH, and this inhibition occurred in the ouabain-insensitive K-uptake. Inhibition of K-influx by DPH was overcome when [K]0 was raised to 10 mM, and Rb-influx was not sensitive to the inhibitor in 2.5 mM Rb-Ringer. Efflux of tracer K was reduced by DPH in the presence and absence of ouabain. Exchange of muscle Na was not affected under condit in which K-exchange was significantly reduced, but DPH appeared to cause increased net loss of Na from muscles washed in Na-free medium. The inhibition by DPH of resting K-exchange was not sensitive to wide variations in [Na]0 or in [Ca]0. The results suggest that the effect of DPH on frog skeletal muscle in normal ionic environment is to reduce the resting, passive component of K-exchange across the fibre membrane. This effect is discussed in relation to the membrane stabilizing actions of diphenylhydantoin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00587224
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    An analysis of calcium-magnesium antagonism in contractility and ionic balance in isolated trabecular muscle of rat ventricle (1975)
    Springer
    Pflügers Archiv 360 (1975), S. 267-282 
    Details
    ISSN: 1432-2013
    Keywords: Myocardium ; Calcium-Magnesium Antagonism ; Contractility, 45-Ca Exchange
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The influence of elevated Mg (20 mM) on mechanical response, fibre electrolyte composition and Ca-exchange, as a function of external Ca concentration, has been studied in an isolated trabecular muscle column of rat ventricle. At [Ca]0 2.5 mM, cellular Mg-content increased in 20 mM [Mg]0 without effect on contractility or fibre content of other electrolytes. As [Ca]0 was reduced from 2.5 mM, 20 mM Mg caused progressive inhibition of contractile response of muscle to electrical stimulation. In both resting and stimulated trabeculae the intrafibre Mg-content rapidly increased and Ca-content fell in the initial 20 min incubation in reduced (1.5 or 0.75 mM) Ca, as the contractile response declined. Subsequent restoration of [Ca]0 to 2.5 mM restored contractile response in the presence of high Mg concentration. Exposure of trabeculae to high Mg also caused a significant decrease in 45-Ca exchange in a muscle calcium-pool exchanging witht1/2 7 min when [Ca]0 was 1.5 mM, but had no effect on Ca-exchange when [Ca]0 was 2.5 mM. The effect of high Mg on exchange of Ca indicated that displacement of a fraction of superficially-bound muscle Ca was responsible for the diminished contractile response in Mg-loaded trabeculae.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00583721
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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