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  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Pharmacology, Biochemistry and Behavior 49 (1994), S. 911-920 
    ISSN: 0091-3057
    Keywords: Anxiety ; Conditioned fear stress ; Dopamine ; Footshock stress ; Freezing behavior ; Medial prefrontal cortex ; Psychological stress ; Serotonin ; Stress intensity
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Psychopharmacology 123 (1996), S. 182-186 
    ISSN: 1432-2072
    Keywords: Anxiety ; Conditioned fear stress ; Freezing behavior ; Serotonin reuptake inhibitors ; Citalopram ; Fluvoxamine ; Milnacipran
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Conditioned fear stress (CFS)-induced freezing behavior has been proposed as an animal model of anxiety. In the present study, freezing was used to determine the anxiolytic activity of selective serotonin reuptake inhibitors (SSRIs), which are reported to be clinically effective in anxiety disorders. The duration of freezing behavior was reduced by acute treatment with the SSRIs citalopram (1–10 mg/kg) and fluvoxamine (3–30 mg/kg). Acute treatment with the serotonin (5-HT)/noradrenaline (NA) mixed reuptake inhibitor milnacipran (3–30 mg/kg) also attenuated CFS-induced freezing, while acute treatment with the NA reuptake inhibitors maprotiline and ORG4428, and the dopamine (DA) reuptake inhibitor GBR12909 failed to alter CFS-induced freezing. These results indicate that facilitation of 5-HT availability in the brain produced by 5-HT reuptake inhibition reduces CFS-induced freezing behavior. CFS may be a useful model for detecting the anxiolytic potential of 5-HT reuptake inhibitors.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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