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Alterations of inhibitory processes in the dentate gyrus following kindling-induced epilepsy (1985)

Oliver, M. W. ; Miller, J. J.

Springer

Experimental brain research 57 (1985), S. 443-447

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ISSN: 1432-1106

Keywords: Epilepsy ; GABA ; Hippocampus ; Inhibition ; Kindling

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary In vitro hippocampal slices were prepared from control and commissural-kindled rats and the inhibitory processes of the dentate granule cells were assessed using paired perforant path stimulation. An early (20 ms) Cl--dependent and a late (200 ms-8 s) Cl--independent inhibition were shown to be present in the dentate. Enhancement of the late Cl--insensitive inhibition was observed following the establishment of commissural kindling and persisted for periods of up to eight weeks following the last seizure.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00237830

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