ISSN:
1432-1912
Keywords:
Gammahydroxybutyric Acid
;
GABA
;
Substantia nigra
;
Inhibition
;
Dopamine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Injections of gammahydroxybutyric acid or gammaaminobutyric acid (GABA), but not betahydroxybutyric acid or carnitine, into the substantia nigra induced increases in brain dopamine of rats. No effect was found after injections into the neostriatum. The noradrenaline in the forebrain was unchanged after all the treatments. Gammahydroxybutyric acid may act by directly or indirectly mimicking an inhibitory GABA mechanism on the dopamine cells in the substantia nigra.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00502071
Permalink