ISSN:
1573-2568
Keywords:
CLARITHROMYCIN
;
HELICOBACTER PYLORI
;
GASTROINTESTINAL MOTILITY
;
MANOMETRY
;
MIGRATING MOTOR COMPLEX
;
PROKINETIC DRUGS
;
STOMACH
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Gastroduodenal motility of 16 patientscomplaining of functional dyspepsia and Helicobacterpylori gastritis was recorded by means of alow-compliance manometric system with four recordingports in the stomach and four in the duodenum.Clarithromycin (CLA) 250 mg (group A: 8 patients) ornormal saline solution (group B: 8 patients) was infusedintravenously randomly and in double-blind manner 30 minafter the end of the first recorded activity front(AF) of the migrating motor complex or, in the absenceof AFs, after 200 min of recording, continuing therecording until an AF was observed during the subsequent 200 min. CLA administration was followed by atypical gastroduodenal AF in a significantly highernumber of patients than saline administration. Inaddition, the time-lag between the drug administration and the appearance of AFs was 22 min ±7.4 (mean ± SD), significantly shorter than aftersaline (109 ± 56 min) and the CLA-relatedduodenal AFs showed a duration of 7.4 min ± 1.6in group A, significantly longer than that of the spontaneous AFs (3.5min ± 1), while in group B AF duration aftersaline was not significantly different from that of thespontaneous ones. In conclusion, clarithromycin is able to stimulate cyclic interdigestivegastroduodenal motility. This prokinetic property ofclarithromycin is not unexpected because it is amacrolide like erythromycin, the prokinetic activity ofwhich is well known, and could be utilized fortherapeutic uses.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1026674719476
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