ISSN:
1617-4623
Keywords:
Nuclear matrix attachment
;
GATA
;
Chicken globin genes
;
DNA-binding protein
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Abstract The sequence-specific DNA-binding protein factor F6, which binds upstream of the cluster of the chicken α-globin genes, has previously been found to interact with a DNA fragment containing a replication origin and a nuclear matrix binding site. This protein has been partially characterized. Based on its molecular weight and binding affinity, F6 belongs to a family of GATA proteins, the chicken equivalent of transcription factor NFE-1. An oligonucleotide including the binding site for F6 competes for binding of the above-mentioned DNA fragment to the nuclear matrix. This indicates an involvement of this protein in the interaction between DNA and the nuclear matrix.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00291988
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