ISSN:
1573-2568
Keywords:
MUCOSAL TURNOVER
;
PEPTIC ULCER DISEASE
;
GROWTH FACTORS
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract In order to investigate whether chronic duodenalulcer disease is a consequence of disturbed mucosalturnover and growth factor expression, we studied 16patients with duodenal ulcers before, during, and after endoscopic healing with lansoprazole orsucralfate. Before treatment, gastric fundal and antralmucosal protein turnover rates were higher in patientsthan controls, without parallel increases in growth factors. Both forms of therapy producedsimilar changes, with overall increases in duodenalmucosal turnover and transforming growth factor-α(TGF-α) and epidermal growth factor receptor (EGF-r) levels. Measurements after healingshowed persistent elevations of mucosal turnover in theantrum and duodenum and depressions of basic fibroblastgrowth factor (bFGF) in gastric fundal and duodenal mucosa. We conclude that mucosal turnover isabnormally high in patients with chronic duodenal ulcerdisease and is not easily explained by growth factorchanges. The failure of lansoprazole and sucralfate to normalize rates, despite endoscopic healing,may explain the high ulcer relapse rates innon-HP-eradicated patients.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1026680017329
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