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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 260 (1968), S. 269-274 
    ISSN: 1432-1912
    Keywords: Substance P ; Physalaemin ; Gall Bladder ; Pancreatic Secretion ; Substanz P ; Physalämin ; Gallenblase ; Pankreas-Sekretion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 1. Substanz P-Extrakt aus Hirn (4150 E/mg Protein) und das Physalämin-ähnliche Peptid Pro-Asp(NH2)-Lys-Phe-Tyr-Gly-Leu-Eti-NH2 kontrahieren beim Hund die Gallenblase und stimulieren die Pancreas-Sekretion. Die Sekretion von Lebergalle bleibt konstant oder nimmt ab. Die Wirkung des Substanz P-Extraktes wird durch Inkubation mit Chymotrypsin zerstört. 2. Roher Substanz P-Extrakt aus Darm (22 E/mg Protein) wirkt wesentlich stärker als Hirnextrakt, wahrscheinlich wegen seines zusätzlichen Gehaltes an Sekretin und/oder Cholecystokinin. 3. Substanz P ist auch in diesen Wirkungen dem Physalämin und seinen Abkömmlingen sehr ähnlich.
    Notes: Summary 1. Substance P-extract from brain (4150 u/mg protein) and the physalaemin-like peptide Pro-Asp(NH2)-Lys-Phe-Tyr-Gly-Leu-Eti-NH2 contract the gall bladder and stimulate pancreatic secretion in the dog. Hepatic bile flow remains constant or is decreased. The activity of the substance P-extract is destroyed by incubation with chymotrypsin. 2. Crude substance P-extract from the intestine (22 u/mg protein) is much more effective than brain extract, probably because of its additional content of secretin and/or cholecystokinin. 3. In these actions, as in others, a close similarity between substance P and physalaemin derivatives is evident.
    Type of Medium: Electronic Resource
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