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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 261 (1968), S. 89-92 
    ISSN: 1432-1912
    Keywords: Gastric secretion ; Gastrin-tetrapeptide ; “Antigastrin” ; Magensekretion ; Gastrin-Tetrapeptid ; „Antigastrin“
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. The effect of “antigastrin” (SC-15 396) on gastric acid and pepsin secretion produced by the gastrin-analogue tetrapeptide amide Try. Met. Asp. Phe-NH2 and by electrical stimulation of the vagus was investigated in anaesthetized gastric fistula cats. 2. “Antigastrin” failed to inhibit both acid and pepsin response stimulated by either the tetrapeptide or vagus excitation. 3. It was concluded that the ineffectiveness of “antigastrin” in cats is due to a species difference between rats and dogs on the one hand and cats on the other, and that “antigastrin” is not a specific gastrin antagonist.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 263 (1969), S. 450-461 
    ISSN: 1432-1912
    Keywords: Cats ; Histamine ; Gastrin-Tetrapeptide ; Vagus Stimulation ; 14C-l-Glutamic Acid ; Gastric Juice ; Pepsin ; Katzen ; Histamin ; Gastrin-Tetrapeptid ; Vagusreizung ; 14C-l-Glutaminsäure ; Magensaft ; Pepsin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 1. An Katzen wurde die Ausscheidung von Radioaktivität in den Magensaft nach i.v. Injektion von 14C-l-Glutaminsäure unter verschiedenen sekretorischen Reizen untersucht. 2. Radioaktives Material wird in Abhängigkeit vom verwendeten Sekretionsreiz in unterschiedlicher Menge ausgeschieden. 3. Die Menge ausgeschiedener Radioaktivität verlief parallel zur Pepsinausscheidung. 4. Lyophilisierter Magensaft mit hohem Pepsingehalt weist bei der Gelfiltration in den Fraktionen die höchste Radioaktivität auf, die auch am meisten Pepsin enthalten. 5. Aus den Versuchen wird geschlossen, daß 14C-Glutaminsäure in der Magenschleimhaut in Pepsin eingebaut und mit diesem in den Magensaft ausgeschieden wird.
    Notes: Summary 1. The effect of different gastric secretagogues on the secretion of radioactive material into the gastric juice after i.v. injection of 14C-l-glutamic acid was investigated in cats. 2. Radioactive material was secreted into the gastric juice in different quantities depending on the stimulus applied. 3. The amount of radioactivity secreted was in parallel with the secretion of pepsin. 4. Fractionation of freeze dried gastric juice of high pepsin content demonstrated a parallelism between radioactivity and pepsin. 5. It is concluded that 14C-l-glutamic acid is incorporated into the pepsin molecule and is secreted with it into the gastric juice.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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