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  • 1995-1999  (2)
  • Gastrointestinal permeability  (1)
  • Key words. Yeast; aging; senescence; helicase; silencing; nucleolus; metabolism; retrograde signaling.  (1)
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Years
  • 1995-1999  (2)
Year
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Yeast aging research: recent advances and medical relevance (1999)
    Springer
    Cellular and molecular life sciences 56 (1999), S. 807-816 
    Details
    ISSN: 1420-9071
    Keywords: Key words. Yeast; aging; senescence; helicase; silencing; nucleolus; metabolism; retrograde signaling.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. The molecular mechanisms of aging are most fully understood for the budding yeast Saccharomyces cerevisiae. Recent advances in our understanding of aging in this organism have enabled researchers to answer some fundamental questions about the aging process. Is aging due to a multitude of ‘mechanisms’ or can there be a key few? Can we design single-gene mutations that will prolong life? Can we prolong life whilst maintaining health and fecundity? The various contributing factors to yeast longevity, uncovered thus far, fall into three classes: DNA metabolism, heterochromatin, and metabolic activity. However, these separate classes may actually represent different aspects of the same aging mechanism based on genome stability. This review examines the recent advances in our understanding of yeast aging and discusses their relevance, if any, to the human condition.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000180050027
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Gastrointestinal permeability following cardiopulmonary bypass: a randomised study comparing the effects of dopamine and dopexamine (1997)
    Springer
    Intensive care medicine 23 (1997), S. 510-516 
    Details
    ISSN: 1432-1238
    Keywords: Key words Cardiopulmonary bypass ; Gastrointestinal permeability ; Dopexamine ; Dopamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: To compare the effects of dopexamine and dopamine on the mucosal permeability of the gastrointestinal tract (GIT). Design: Prospective, randomised clinical trial. Setting: Intensive care unit of a postgraduate teaching hospital, London, England. Patients: Thirty patients undergoing elective surgery involving cardiopulmonary bypass, performed by a single surgeon. Interventions: Patients were randomly assigned to receive either dopexamine 2.0 μg/kg per min or dopamine 2.5 μg/kg per min for the duration of the study period. Measurements and main results: Hemodynamic parameters and gastric intramucosal pH (pHi) were measured at intervals throughout the study. GIT permeability was measured once, post-operatively, using the ratio of absorbed lactulose to L-rhamnose. The groups were similar with respect to demographics, pre- and post-operative risk factors. The lactulose/rhamnose ratio was (mean ± SEM) 0.44 ± 0.10 in the dopexamine group vs 0.65 ± 0.08 in that receiving dopamine (p 〈 0.05). The dopexamine group had a significantly higher oxygen delivery preoperatively (479.5 ± 32.0 ml/min per m2 vs 344.4 ± 23.9 ml/min per m2 for dopamine, p 〈 0.01), but no other significant differences emerged between the groups. Conclusions: Compared to dopamine, dopexamine reduces GIT permeability following surgery involving cardiopulmonary bypass. The mechanism of this effect remains unclear.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001340050366
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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