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  • 1
    ISSN: 1432-0584
    Keywords: Anthracyclines ; Verapamil ; Bone marrow progenitors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Drug-induced myelotoxicity is usually the dose-limiting factor of treatment of malignant tumors with cytostatic drugs. Suppression of in vitro myelopoiesis (CFU-GM) by cytostatics may be a suitable model reflecting the in vivo situation. Thus the inhibitory effects of the anthracyclines doxorubicin, theprubicin, idarubicin and cytorhodin S on CFU-GM were compared. Normal human bone marrow cells were incubated with these drugs for one hour and alternatively, for the whole culture period. For each substance and each incubation time a dose-response curve was established and the D50 determined. As certain calcium antagonists can increase the toxicity of some cytostatic drugs in various tumor models, the effect of the addition of verapamil (2µM) was also investigated. It could be shown, that the myelotoxicity on CFU-GM of the drugs mentioned above was not increased after short-term or permanent exposure to this calcium antagonist.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 361 (1983), S. 653-655 
    ISSN: 1435-2451
    Keywords: Cervical biopsy ; Neurological complications ; Suitable anaesthesia ; Probeexcision im Halsbereich ; Neurologische Komplikationen ; Geeignete Anaesthesie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 433 Patienten mit Probeexcision im Bereich des Halses fanden sich neben Lymphadenitiden in erster Linie hämatologische Malignome und Metastasen maligner Tumoren. In 4,8 % traten behandlungsbedürftige Komplikationen auf, zum einen Wundheilungsstörungen (Hämatome, Entzündungen), zum zweiten neurologische Komplikationen des Nervus accessorius. Bei 4 Patienten bildeten sich diese vollständig zurück, einmal blieb eine Parese des Musculus deltoideus bestehen. Die Analyse des Krankengutes läßt erkennen, daß vor allem ungeeignete Narkoseverfahren (Lokalanaesthesie) bei in der Tiefe gelegenen, schlecht abgrenzbaren Tumoren zu Komplikationen geführt hatten.
    Notes: Summary In 433 cervical biopsies lymphadenitis, metastases of malignant tumors and of the haematologic system could be found first of all. In 4.8 % complications needed a further treatment, firstly trouble in wound healing (haematoma, inflammation), secondly neurological complications of the accessorial nerve. These complications receded in 4 patients completely, in one patient a paralysis of the deltoid muscle continued. The analysis of our patients suggested that unsuitable anaesthesia (local anaesthesia) for deeper-seated, badly demarked tumors is responsible for most of the complications.
    Type of Medium: Electronic Resource
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