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Sodium-23 NMR and complex impedance studies of gel electrolytes based on poly (acrylonitrile)

Stallworth, P.E. ; Li, J. ; Greenbaum, S.G. ; [et al.]

Amsterdam : Elsevier

Solid State Ionics 73 (1994), S. 119-126

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ISSN: 0167-2738

Keywords: Gel electrolytes ; NMR study of Na^+ motion ; Poly (acrylonitrile) gels

Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Topics: Physics

Type of Medium: Electronic Resource

URL: http://linkinghub.elsevier.com/retrieve/pii/0167-2738(94)90271-2

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Conductance of 1:1 electrolytes in methyl formate (1987)

Plichta, E. ; Salomon, M. ; Slane, S. ; [et al.]

Springer

Journal of solution chemistry 16 (1987), S. 225-235

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ISSN: 1572-8927

Keywords: Conductivities ; 1:1 electrolytes ; methyl formate ; ion pairs ; triple ions ; ion solvation

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology

Notes: Abstract The electrolytic conductivities of LiClO4, LiAlCl4, LiAsF6, NaClO4, NaBPh4, and Bu4NClO4 have been measured in methyl formate at 25°C. Evidence is presented for strong association between the perchlorate ion and the formyl proton of the solvent. Ion association and triple ion formation constants suggest that LiClO4, LiAlCl4, and NaClO4 form solvent separate ion pairs and triple ions. NaBPh4 forms contact ion pairs and triple ions, and the remaining salts appear to form both types of ion pairs and triple ions.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00646988

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Pharmacokinetic/pharmacodynamic interactions of intensive cyclophosphamide, cisplatin, and BCNU in patients with breast cancer (1993)

Jones, Roy B. ; Matthes, Steven ; Dufton, Christopher ; [et al.]

Springer

Breast cancer research and treatment 26 (1993), S. S11

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ISSN: 1573-7217

Keywords: autologous hematopoietic cell support ; BCNU ; breast cancer ; carboplatin ; cisplatin ; cyclophosphamide

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Combinations of alkylating agents in intensive doses with autologous hematopoietic cell support (AHCS) are commonly used to treat advanced, solid tumors. Relatively little is known about the pharmacokinetic or pharmacodynamic aspects of their use. The cyclophosphamide, cisplatin, and BCNU (CPA/cDDP/BCNU) regimen is often used in patients with breast cancer. In these individuals, the blood levels of BCNU vary by more than tenfold. In rats given BCNU, the blood level variability is associated with cisplatin pretreatment, and mean levels are much higher than those that occur when cisplatin pretreatment is omitted. These observations suggest that a major elimination pathway for BCNU is metabolic and is subject to cisplatin disruption. Between 30–50% of patients receiving the CPA/cDDP/BCNU regimen experience a steroid-responsive pulmonary injury that can be fatal if untreated. Blood levels of BCNU are positively correlated with the risk of pulmonary injury in these patients. Others have demonstrated that blood levels of CPA can be inversely correlated with the likelihood of cardiac toxicity and 2-year, relapse-free survival in patients with breast cancer. Emerging data suggest that circulating drug levels, rather than the calculated dose, best explain the variability of outcome in patients treated with combination alkylating agents and AHCS.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00668355

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