ISSN:
1432-1440
Keywords:
Key words Extracellular matrix
;
Gene targeting
;
Transgenic mice
;
Mouse models
;
Human diseases
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Mutations of a number of genes encoding for extracellular matrix (ECM) proteins in mice have provided new insights regarding their role during development and disease. Many mouse strains have helped to verify the link between mutation and disease in humans, and others have produced unexpected phenotypes and identified new functions for ECM proteins. Finally, some null mutations in ECM genes provide no phenotypic alterations in mice, confronting the scientific community with a new challenge to search for their functions. This review lists all mouse strains with spontaneous and experimentally induced mutations in ECM genes. The phenotypes of these mice are discussed in comparison with the human diseases.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s001090050214
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