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  • 1
    ISSN: 1573-7284
    Keywords: Human hepatitis A virus ; T1oligonucleotide fingerprinting ; Genomic stability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Three human hepatitis A virus strains, all of them isolated in Italy but one acquired abroad, were analyzed by T1 - RNAase oligonucleotide mapping and by monoclonal antibody neutralization. The variation among their genomes according to T1 - maps was calculated to be about 9%, thus confirming the poor genomic variation assessed by nucleotide sequencing (1 – 10%). However T1 - maps of these Italian isolates were different from those reported in the literature (Weitz and Siegl, 1985). Neutralization by monoclonal antibody caused a reduction in titres of 2 – 2.5 log10. This genomic stability, if confirmed, is important with a view to a valuable vaccine.
    Type of Medium: Electronic Resource
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