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Organization of specific DNA sequence elements in the region of the replication origin and matrix attachment site in the chicken α-globin gene domain (1992)

Krajewski, W. A. ; Razin, S. V.

Springer

Molecular genetics and genomics 235 (1992), S. 381-388

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ISSN: 1617-4623

Keywords: Bent DNA ; DNA melting pattern ; Replication origin ; Matrix attachment site ; Globin genes

Source: Springer Online Journal Archives 1860-2000

Topics: Biology

Notes: Summary The distribution of specific DNA sequence elements in a 2.9 kb HindIII fragment of chicken DNA containing the replication origin and the upstream matrix attachment site (MAR) of the α-globin gene domain was investigated. The fragment was shown to contain a CR1-type repetitive element and two stably bent DNA sequences. One of them colocalizes with the previously described MAR element and with the recognition site for a proliferating-cell-specific, DNA-binding protein. The melting pattern of a set of subfragments of the region proved to be non random. No correlation between the distribution of readily melting sequences and bent DNA was found. The possible importance of curved, low-melting and repetitive DNA sequences for the organization of the upstream boundary of the α-globin gene domain and the function of the replication origin is discussed.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00279384

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DNA interactions with the nuclear matrix and spatial organization of replication and transcription (1987)

Razin, S. V.

New York, NY : Wiley-Blackwell

BioEssays 6 (1987), S. 19-23

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ISSN: 0265-9247

Keywords: Life and Medical Sciences ; Cell & Developmental Biology

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Biology , Medicine

Notes: Analysis of the DNA sequence associated with the nuclear matrix has made it possible to identify several types of DNA matrix association. Permanent attachment sites are detected in both transcriptionally active and inactive nuclei. Furthermore, replication origins have been shown to be permanently attached to the nuclear matrix. In transcriptionally active nuclei, expressed genes are also associated with the nuclear matrix. Finally, a special group of attachment sites is described; these sites are believed to maintain the fixed positions of individual chromosomes in interphase nuclei.

Additional Material: 2 Ill.