ISSN:
1432-0428
Keywords:
Glucagon-like peptide-1 receptor
;
non-insulin-dependent diabetes mellitus
;
maturity onset diabetes of the young
;
polymerase chain reaction
;
linkage analysis
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Glucagon-like peptide-1 (GLP-1) is a hormone derived from the preproglucagon molecule that is secreted by intestinal L cells and stimulates insulin secretion from betacells. The GLP-1 receptor is a candidate gene for diabetes mellitus, as mutations may induce the impaired insulin response that is a characteristic feature of NIDDM. To study the relationship between the GLP-1 receptor gene and NIDDM, linkage of a microsatellite polymorphism flanking the GLP-1 receptor gene with diabetes was investigated in three Caucasian families with MODY and in the nuclear families of 12 NIDDM probands. A cumulative LOD score −8.50 excludes linkage in these MODY pedigrees. A LOD score of −1.24 in the NIDDM nuclear pedigrees makes linkage improbable. Mutations in or near the GLP-1 receptor gene are unlikely to be the major cause of the inherited predisposition to NIDDM in Caucasian pedigrees, but we cannot exclude a role for this locus in a polygenic model or a major role in some pedigrees.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00417698
Permalink
