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Regional Spinal Cord Blood Flow and Energy Metabolism in Rats after Laminectomy and Acute Compression Injury (2000)

Mautes, Angelika E. M. ; Schröck, Helmut ; Nacimiento, Amadeo C. ; [et al.]

Springer

European journal of trauma 26 (2000), S. 122-130

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ISSN: 1615-3146

Keywords: Key Words Spinal cord compression ; Autoradiography ; Blood flow ; ATP ; Glucose ; Lactate ; Bioluminescence ; Rat

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Many data are available concerning spinal cord blood flow (SCBF) and metabolism on various models and timing after spinal cord injury, however, detailed information on their exact relationship in the same injury model is lacking. This relationship is a crucial factor in the understanding of the pathophysiology of spinal cord trauma. Rats were subjected to lumbar laminectomy or lumbar spinal cord compression trauma. 3 hours later, changes in SCBF were evaluated autoradiographically and changes in ATP, glucose and lactate levels were analyzed using substrate-specific bioluminescence techniques. Measurements were performed at the lesion site (segment L4), adjacent segments (L3 and L5) and at remote thoracic segments (Th8 to Th9). Laminectomy alone did not change SCBF, both in thoracic and lumbar segments. In contrast, ATP levels were significantly reduced and lactate levels were increased at the lesion site and in adjacent lumbar segments at 3 hours after laminectomy, whereas glucose levels were not significantly changed. In animal subjected to additional compression trauma, SCBF was significantly reduced in segments L3, L4 and L5 paralleled by a significant ATP reduction and lactate increase. Glucose levels did not differ significantly from controls 3 hours after compression injury. This metabolic profile was also reflected in the remote thoracic segments. In contrast, SCBF was not reduced in thoracic segments of traumatized animals. The observation that ATP was already significantly reduced and lactate increased in laminectomized segments and in remote thoracic regions after trauma signals that metabolic changes are sensitive indicators to spinal stress. The fact that posttraumatic metabolic profile differs from the pattern of hemodynamic and metabolic changes induced by ischemia, suggests posttraumatic mediators may be involved in the different regulation of the energy producing machinery.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/s000680050010

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Disiloxanes, Disilazanes and Related Compounds Derived from 1,8-DisilynaphthaleneDedicated to Frau Professor M. Baudler on the occasion of her 75th birthday. (1996)

Schröck, Robert ; Dreihäupl, Karl-Heinz ; Sladek, Alexander ; [et al.]

Weinheim : Wiley-Blackwell

Berichte der deutschen chemischen Gesellschaft 129 (1996), S. 495-501

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ISSN: 0009-2940

Keywords: 1,8-Disilylnaphthalene ; Disiloxane ; Disilthiane ; Disilazanes ; Phosphonium bis(silyl)methylide based on 1,8-disilylnaphthalene ; Chemistry ; Inorganic Chemistry

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: The synthesis, spectroscopic data and molecular structures of heterocycles derived from 1,8-disilylnaphthalene are reported. The key intermediate for the preparation of the title compounds is 1,8-bis[(trifluoromethylsulfonyl)silyl]naphthalene (3), which is prepared from 1,8-bis[(4-methoxyphenyl)silyl]naphthalene (2) by treatment with two equivalents of triflic acid in toluene at -20°C. The resulting silyl triflate is stable only below this temperature and was not isolated. Its reactions with water, ammonia, amines, and sulfane give the corresponding disiloxane, disilazanes and disilthiane. The molecular structure of Si,Si′-(Naphthalene-1,8-diyl)-N-phenyldisilazane (8) was determined by X-ray diffraction. Treatment of 2 with substoichiometric amounts of triflic acid and subsequent reaction of the resulting monosilyl triflate with tert-butylamine gives a related chiral N-tert-butyl-Si-(4-methoxyphenyl)disilazane 10. Its molecular structure was proven by X-ray diffraction. A cyclic phosphonium bis(silyl)methylide (11) was synthesized by a transylidation process using 3 and CH2=P(NMe2)3. The structure of 11 was also determined by X-ray diffraction.

Additional Material: 6 Ill.