ISSN:
1432-1459
Keywords:
Olivopontocerebellar atrophy
;
Glutamate dehydrogenase
;
Platelets
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The activity of glutamate dehydrogenase, the enzyme of glutamate degradation, was measured in platelets of 27 healthy controls and 85 patients with different degenerative cerebellar and/or basal ganglia disorders. A group of 7 patients was selected with slowly progressive multiple-system atrophy, in whom a clinical diagnosis of olivopontocerebellar atrophy appeared tenable, with decreased activity of glutamate dehydrogenase (38% of the mean control value). In 4 patients data on inheritance were compatible with the genetic pattern of autosomal recessive inheritance, while 3 patients were sporadic cases. In an effort to define this group of patients more precisely, it is suggested that decreased activity of glutamate dehydrogenase induces an increase in extracellular glutamate levels in the central nervous system with subsequent development of excitotoxicity.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00314407
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