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  • 1
    Digitale Medien
    Digitale Medien
    Mucosal metabolism in ulcerative colitis and crohn's disease (1998)
    Springer
    Diseases of the colon & rectum 41 (1998), S. 1399-1405 
    Details
    ISSN: 1530-0358
    Schlagwort(e): Butyrate ; Glutamine ; Metabolism ; Ulcerative colitis ; Crohn's disease
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract PURPOSE: Colonic mucosal metabolism of butyrate may be impaired in ulcerative colitis. In this study we sought to confirm this observation, to determine if a similar change occurs in Crohn's colitis, and to establish whether a panenteric disorder of butyrate metabolism exists in either condition. METHODS: With use of a microculture technique, mucosal metabolic fluxes of14[C]-labeled butyrate and14[C]-labeled glutamine were measured as14[C] carbon dioxide production in mucosal biopsy specimens from the colon and ileum in patients with ulcerative colitis, Crohn's colitis, and healthy bowel. Results were expressed as pmol/µg biopsy DNA/hour. RESULTS: In the colon the mucosal metabolic fluxes of both butyrate and glutamine are reduced in both ulcerative colitis and Crohn's colitis compared with healthy controls. These changes were most marked in the presence of moderate to severe mucosal inflammation, there being no significant difference in mucosal metabolic flux between mildly inflamed mucosa and healthy controls. In the ileum the mucosal metabolic fluxes of butyrate and glutamine did not differ between healthy controls and those with either ulcerative colitis or Crohn's colitis. CONCLUSIONS: Changes in colonic mucosal metabolism of butyrate and glutamine in inflammatory bowel disease occur as a consequence of the inflammatory process and are not peculiar to ulcerative colitis. Ileal mucosal metabolism is unchanged in ulcerative colitis and Crohn's colitis, indicating the absence of a panenteric abnormality of mucosal metabolism in these two conditions.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02237056
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  • 2
    Digitale Medien
    Digitale Medien
    The influence of storm characteristics and catchment conditions on extreme flood response : A case study based on the brue river basin, U.K. (1995)
    Springer
    Surveys in geophysics 16 (1995), S. 201-225 
    Details
    ISSN: 1573-0956
    Schlagwort(e): Extreme floods ; Storm transposition ; Rainfall-runoff models ; SHE
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Geologie und Paläontologie , Physik
    Notizen: Abstract Methods for estimating the magnitude of extreme floods are reviewed. A method which combines a probabilistic storm transposition technique with a physically-based distributed rainfallrunoff model is described. Synthetic storms with detailed spatial and temporal distributions are generated and applied to the calibrated model of the Brue river basin, U.K. (area 135 km2). The variability of catchment response due to storm characteristics (storm area, storm duration, storm movement, storm shape and within storm variation) and initial catchment wetness conditions is investigated. A probabilistic approach to estimating the return periods of extreme catchment responses is suggested.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00665780
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