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Gold: Hepatotoxic and cholestatic reactions (1985)

Hanissian, A. S. ; Rothschild, B. M. ; Kaplan, S.

Springer

Clinical rheumatology 4 (1985), S. 183-188

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ISSN: 1434-9949

Keywords: Gold ; Rheumatoid Arthritis ; Juvenile Rheumatoid Arthritis ; Hepatotoxiciy

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Gold hepatotoxicity is an uncommon but significant clinical problem. Hepatitis was first manifested one day to four weeks after the last dose of gold at a cumulative range of 35 to 2900 mg. An interesting dichotomy was noted between cholestatic and hepatotoxic reactions. Hepatotoxic reactions were associated with other clinical signs of hyper-sensitivity, thus facilitating differential diagnosis from viral hepatitis. Sudden clinical improvement in a patient receiving gold should stimulate evaluation for a hepatotoxic reaction.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF02032291

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