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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 62 (1984), S. 675-688 
    ISSN: 1432-1440
    Keywords: Immunohistology ; Skin alterations ; Graft-versus-host disease ; Bone marrow transplantation ; Langerhans cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Skin biopsies of 26 patients with leukemia and seven patients with aplastic anemia were investigated before and at different stages after allogeneic bone marrow transplantation (BMT) to establish the immunological criteria which distinguish skin alterations during normal reconstitution from dermal lesions mediated by graft-versushost disease (GvHD). Of the 33 patients studied 27 presented with clinically diagnosed acute and/or chronic GvHD, one patient died of bone marrow rejection. Immunohistological analysis of the respective skin biopsies with selected monoclonal antibodies against human leukocyte antigens (HLA) and differentiation antigens of the lympho-hematopoietic cells revealed low dermal mononuclear cell counts with phenotypically normal constituents in five cases with uncomplicated reconstitution post-grafting. In contrast, increased dermal cellular infiltrates predominantly consisting of Lyt 3+, OKT 8+ T-lymphocytes, as well as of a large number of Ia-like (immune response associated = HLA-D) determinant+ monocytes/macrophages were observed in all patients with active acute/chronic GvH reactivity. As sign of activation simultaneous expression of HLA-D region products was also found on a subset of the invading OKT 8+ T-lymphocytes. Progression of GvHD was associated with additional surface staining of keratinocytes for Ia-like determinants. Loss of Ia-like determinant+, OKT 6+ dentritic epithelial cells in all leukemic patients, as well as in patients with aplastic anemia with or without GvHD suggested damage of Langerhans cells due to the previous radiotherapy and/or specific immunological destruction. In patients with fatal outcome of GvHD prolonged reduction of these dentritic epithelial cells seemed to be indicative of impaired immune reconstitution or bone marrow dysfunction. Thus immunopathological features of skin GvHR may enable early recognition and prognostic evaluation of this disease possibly allowing more effective therapy.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Zeitschrift für Gerontologie + Geriatrie 32 (1999), S. 179-192 
    ISSN: 0044-281X
    Keywords: Schlüsselwörter Alter – psychologische Gerontologie –Übersicht – kognitive Entwicklung – Intelligenz – Gedächtnis – Demenz – kognitive Intervention ; Key words Old age – psychological gerontology – review – cognitive development – intelligence – memory – dementia – applied cognitive intervention
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In this four-part review article, an update of psychological gerontology since 1988 in German speaking countries is given als follows: Cognitive development in old age (part I), personality development in old age (part II), social relations in old age (part III), tasks, burdens, and border situations in old age (part IV). In part I of the update which is presented in this issue, the description of recent trends in cognitive research serves as a background to highlight, in a first step, the basic research in the field concerned with the mechanics as well as the pragmatics of intelligence in the later years. In a further step, research on memory processes including psychological work with relevance for the investigation of dementia is reviewed. Finally, cognitive intervention studies reflecting the impact of an applied cognitive gero-psychology and aimed to support the potential and limits of the plasticity of the intelligence and memory development in old age find consideration.
    Notes: Zusammenfassung In diesem vierteiligen Übersichtsartikel wird über die Psychologische Gerontologie in deutschsprachigen Ländern seit 1988 wie folgt berichtet: Kognitive Entwicklung im Alter (Teil I), Persönlichkeitsentwicklung im Alter (Teil II), soziale Beziehungen im Alter (Teil III) und Aufgaben, Belastungen und Grenzsituationen im Alter (Teil IV). In Teil I der Übersichtsarbeit in diesem Heft wird vor dem Hintergrund einer Beschreibung von allgemeinen Trends der kognitiven Forschung im Alter zunächst die Literatur zur Mechanik und Pragmatik der Intelligenz beleuchtet. In einem weiteren Schritt stehen Forschungsarbeiten zum alternden Gedächtnis im Mittelpunkt, wobei auch psychologische Studien mit Relevanz für die Erforschung der Demenz Berücksichtigung finden. Die Arbeit schließt mit einer Zusammenstellung von Beiträgen zu einer angewandten kognitiven Alternspsychologie, wobei insbesondere auf Trainingsstudien zur Abschätzung der Möglichkeiten und Grenzen von kognitiven Interventionen im Alter eingegangen wird.
    Type of Medium: Electronic Resource
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