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  • 1
    ISSN: 1432-0533
    Keywords: Free-living amebas ; Encephalitis ; Granuloma ; Acanthamoeba ; Naegleria ; “Mycotic aneurysm”
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Primary amebic meningoencephalitis and granulomatous amebic encephalitis are well recognized clinicopathological entities caused by free-living amebas. Associated arteritis and “mycotic aneurysms” with infiltration of intracranial arteries by lymphocytes, amebic trophozoites and cysts have not been previously reported. A 26-month-old girl had a 3-week history of encephalitis, characterized, initially, by vomiting and lowgrade fever. Subsequently, she developed ataxia, generalized weakness, lethargy, and esotropia. The first CSF showed 490 RBC/μl, 705 WBC/μl with 90% mononuclears. Her pupils reacted briskly to light. Moderate nuchal rigidity, nystagmus, fixed downward gaze, anisocoria, bilateral 6th nerve palsy, left arm monoparesis and left Babinski were present. CAT scan revealed slight symmetrical dilatation of anterior horns of lateral ventricles and an area of abnormal enhancement above the 3rd ventricle. She died 14 days after admission, 5 weeks after onset of symptoms. The brain showed focal necrotizing encephalopathy, involving thalami, cerebellum, brain stem, and cervical and upper thoracic spinal cord. Numerous free-living amebic trophozoites and cysts were present within a chronic granulomatous encephalitis. There were thrombosis of basilar, posterior cerebral, and vertebral arteries with profuse chronic panarteritis, fibrinoid necrosis, and mycotic aneurysms.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0533
    Keywords: Aseptic Meningitis ; Atheromatous Material ; Hypersensitivity ; Electron Microscopy ; Macrophages ; Pia-Arachnoid ; Granuloma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 500 mg of sterile pooled human atheromatous material was injected into the cisterna magna of 6 mongrel dogs. Repeated cisternal punctures were done at various intervals until sacrifice from 1 day to 28 days following injection. CSF was obtained for cell count, sugar, protein and analysis in the Technicon 6/60 which measured 14 additional chemical and enzymatic variables. All 6 animals showed a prompt cerebrospinal fluid (CSF) pleocytosis which largely subsided during the first 2 weeks after injection. Increased CSF protein content developed more slowly, but was more prolonged than the pleocytosis. There was a variable decrease in CSF sugar and increase in CSF lactate dehydrogenase, calcium and inorganic phosphorous. Light and electron microscopic studies showed an intense acute inflammatory reaction with marked phagocytosis of the foregin material, probably by arachnoidal cells and moderate edematous changes in the astrocytic processes at the site of injection. During the first 2 weeks after the injection the inflammatory reaction became chronic and the edematous changes in the medulla subsided.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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