ISSN:
1573-9023
Keywords:
HIV
;
Antiviral agents
;
Resistance
;
Combinations
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary Nucleoside analogs continue to provide a rich source of potent and selective anti-HIV agents. The 5′-triphosphate forms of the clinically useful nucleosides are competitive inhibitors of retroviral reverse transcriptases and can result in the termination of chain elongation of proviral DNA. The function of viral reverse transcriptases and the mechanism of action of various compounds against HIV and hepatitis B virus are discussed. Insights in drug combination and viral resistance to nucleoside analogs are also provided with emphasis on novel enantiomers of nucleosides with the unusuall-configuration.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02171660
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