ISSN:
1573-7284
Schlagwort(e):
HTLV-I
;
HIV-1
;
IgG
;
IgM
;
ELISA
;
Western blot
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Abstract Serum samples collected from four groups of individuals in the Washington, D.C. area were examined for the presence of IgG and IgM classes of antibody reacting against HTLV-1 and HIV-1. These four groups were: (1) healthy adults with negative premarital VDRL test for syphilis (n=113), (2) miscellaneous common disease patients (n=155), (3) drug abusers (n=130), and (4) homosexual men (n=187). The former two groups are considered to be low-risk groups, and the latter two, high-risk groups. The prevalence of IgG antibody on ELISA/Western blot tests for these groups were respectively: (1) 5.3%/1.8%, (2) 5.2%/1.9%, (3) 13.9%/4.6%, and (4) 4.3%/1.6% for HTLV-1, and (1) 2.7%/0.9%, (2) 4.5%/0%, (3) 12.3%/5.4%, and (4) 8.0%/5.9% for HIV-1. Instances of possible concomitant infection as shown by the presence of antibodies against both HTLV-I and HIV-1 were found only in the latter two high-risk groups, i.e. two (1.5%) in group (3), and three (1.6%) in group (4) as confirmed by both Western blot and immunofluorescence tests. Out of 97 sera collected from drug abusers in 1985-86 which had IgG antibody by Western blot test against HIV-1, 23 (23.7%) were HTLV-I antibody positive by ELISA test (Group 5), and 8 of these were confirmed by Western blot test. Among these 8 persons, IgM antibody against HTLV-I was found in 2, while that against HIV-1 was positive in 7 persons. This fact suggests that the exposure to HIV-1 occurred more recently than that with HTLV-I in most of those persons who were dually infected. By cross-absorption studies, it was shown that the dual antibody reactivities were not due to cross-reactivity between HTLV-I and HIV-1.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00146393
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