ISSN:
1432-0428
Keywords:
Type 1 (insulin-dependent) diabetes
;
genetics
;
HLA antigens
;
T-lymphocyte clones
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary We have been using human T-lymphocyte clones specifically sensitized to detect leucocyte antigens of Type 1 (insulin-dependent) diabetic patients in the hope of detecting novel HLA antigens associated with Type 1 diabetes. We previously described two such clones which define a new class II HLA antigen, Boston-1 (BO1). BO1 is found mainly on cells of persons with particular HLA-DR antigens and, of potential significance for diabetes, BO1 identifies a distinctive subset of DR3 haplotypes. We report here that BO1+ DR3 haplotypes are overrepresented in Type 1 diabetes. That is, significantly more of the DR3-positive subjects are BO1-positive in the patient group (31%) than in the control group (8%), suggesting that a diabetes-susceptibility gene may be more common on the BO1+ than on the BO1− DR3 haplotypes. Alternative interpretations are also discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00703131
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